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Tamoxifen Citrate

CAT: 0931-T0835-01Size: 1 mL - 10 mM (in DMSO)Dry Ice: NoHazardous: No
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CAT#:0931-T0835-01Size:1 mL - 10 mM (in DMSO)
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
54965-24-1
Target
Autophagy, Estrogen Receptor/ERR, Estrogen/progestogen Receptor, Apoptosis, HSP
Related Pathways
Cytoskeletal Signaling, Endocrinology/Hormones, Autophagy, Apoptosis, Metabolism
Purity
0.9986
Bioactivity
Tamoxifen Citrate is an orally active selective estrogen receptor modulator (SERM) that blocks estrogen activity in breast cells while activating estrogen signaling in cells such as those of the bone, liver, and uterus. As an Hsp90 activator, it enhances the ATPase activity of the Hsp90 chaperone complex, induces autophagy and apoptosis, and can be used to generate gene knockout models in CreER (T2) transgenic mice as well as liver injury models.
Smiles
CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1.C(C(=O)O)C(CC(=O)O)(C(=O)O)O
Molecular Formula
C32H37NO8
Molecular Weight
563.65
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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