Complement C4 Protein (Active)

CAT: 1510-BNP1007Size: 1 mgDry Ice: NoHazardous: No
CAT#:1510-BNP1007Size:1 mg
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Background
Complement C4encodes the basic form of complement factor 4, part of the classical activation pathway. The protein is expressed as a single chain precursor which is proteolytically cleaved into a trimer of alpha, beta, and gammachains prior to secretion. The trimer provides a surface for interaction between the antigen-antibody complex and other complement components. The alpha chain may be cleaved to release C4 anaphylatoxin, a mediator of local inflammation. Deficiency of this protein is associated with systemic lupus erythematosus. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. Varying haplotypes of this gene cluster exist, such that individuals may have 1, 2, or 3 copies of this gene. In addition, this gene exists as a long form and a short form due to the presence or absence of a 6.4 kb endogenous HERV-K retrovirus in intron 9.
Description
Purified human Complement C4 protein.
Synonyms
Complement C4-A, Acidic complement C4, C3 and PZP-like alpha-2-macroglobulin domain-containing protein 2, C4A, CO4, CPAMD2
Source
Human plasma
Applications
ELISA
Purity
>90% by SDS-PAGE
Buffer
Each vial contains 10mM PBS (pH7.4) .
References & Citations
1.Rosenfeld, S. I., Ruddy, S., Austen, K. F. Structural polymorphism of the fourth component of human complement. J. Clin. Invest. 48: 2283-2292, 1969. 2.Roos, M. H., Mollenhauer, E., Demant, P., Rittner, C. A molecular basis for the two locus model of human complement component C4. Nature 298: 854-856, 1982. 3.Schneider, P. M., Witzel-Schlomp, K., Rittner, C., Zhang, L. The endogenous retroviral insertion in the human complement C4 gene modulates the expression of homologous genes by antisense inhibition. Immunogenetics 53: 1-9, 2001.
Storage Conditions
Shipat 4°C. Upon receipt, aliquot and store at -20°C or -80°C for long term. Avoid repeated freeze and thaw cycles.
Formulation
Liquid

Related Products

CatalogName
BNP1004Complement C3 Protein (Active)
BNP1005Complement C3 Protein (Active)
BRP1009DKK1 Protein (Active)
BRP1064Insulin Protein (Active)
BRP1086SCCA1 Protein (Active)
BNP1028S100BB Protein (Active)
BRP1068Myoglobin Protein (Active)
BRP1087SCCA2 Protein (Active)
BNP1024Prealbumin Protein (Active)
BRP1084S100BB Protein (Active)

Alternative Products

CatalogName
MBS355503-01Complement C4 Protein (Active)
MBS355514-01Complement C3 Protein (Active)
RPU60151-01Human Complement Component 5, Active Protein
RPU60274-01Human Complement C4-B, Active Protein
RPU60248-01Mouse Complement Factor B, Active Protein
RPU60259-01Human Complement Component 4a, Active Protein
RPU60385-01Mouse Complement Component 3a, Active Protein
RPU60748-01Mouse Complement Component 5a, Active Protein
RPU60749-01Mouse Complement Component 4a, Active Protein
RPU60751-01Mouse Complement C4-B, Active Protein

Popular Products