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Pro-BNP Protein (Active)

CAT: 1510-BRP1081Size: 100 μgDry Ice: NoHazardous: No
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CAT#:1510-BRP1081Size:100 μg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Basic natriuretic peptide (BNP), now known as B-type natriuretic peptide (also BNP) or GC-B, is a 32 amino acid polypeptide secreted by the ventricles of the heart in response to excessive stretching of heart muscle cells (cardiomyocytes) . The release of BNP is modulated by calcium ions. BNP is released from the cardiac ventricles in response to increased wall tension. Rapid measurement of BNP is useful in establishing or excluding the diagnosis of congestive heart failure in patients with acute dyspnea. BNP is secreted along with a 76 amino acid N-terminal fragment (NT-proBNP) which is biologically inactive. BNP binds to and activates the atrial natriuretic factor receptors NPRA, and to a lesser extent NPRB, in a fashion similar to atrial natriuretic peptide (ANP) but with 10-fold lower affinity.
Description
Recombinant full length human Pro-BNP protein with molecular weight 17 kDa.
Synonyms
Pro-Brain natriuretic peptide, Pro-BNP, Natriuretic peptides B
Source
E. Coli
Applications
WB; ELISA
Purity
>95% by SDS-PAGE
Buffer
Each vial contains PBS (pH7.5) without preservative.
References & Citations
Ziskoven D, Forssmann WG, Holthausen U, Menz G, Addicks K, Rippegater G: Calcium Calmodulinantagonists Influences the release of Cardiodilatin/ANP from Atrial Cardiocytes. Handbook Endocrinology of the Heart, edited by Kaufmann W, Wambach G, 01/1989; Springer Verlag Berlin Heidelberg New York; ISBN/EAN 978-3-540-51409-1 Maisel A, Krishnaswamy P, Nowak R, McCord J, Hollander J, Duc P, Omland T, Storrow A, Abraham W, Wu A, Clopton P, Steg P, Westheim A, Knudsen C, Perez A, Kazanegra R, Herrmann H, McCullough P (2002) . "Rapid measurement of B-type natriuretic peptide in the emergency diagnosis of heart failure". N Engl J Med 347 (3) : 161–7.
Storage Conditions
Shipat 4°C. Upon receipt, aliquot and store at -20°C or -80°C for long term. Avoid repeated freeze and thaw cycles.
Formulation
Liquid

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