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Recombinant human NEDD8 protein

CAT: 0112-NED0905-020Size: 20 µgDry Ice: NoHazardous: No
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CAT#:0112-NED0905-020Size:20 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
NEDD8 belongs to the ubiquitin family and human NEDD8 shares 60% amino acid sequence identity to ubiquitin. The NEDD8 system is essential for the regulation of protein degradation pathways involved in cell cycle progression, morphogenesis and tumorigenesis. Attachment of NEDD8 to cullins activates their associated E3 ubiquitin ligase activity, and thus promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins. Recombinant human NEDD8 protein was expressed in E. coli and purified by using conventional chromatography techniques, after refolding of the isolated inclusion body in renaturation buffer.
Product Name Alternative
Neural precursor cell expressed developmentally down-regulated 8, ubiquitin-like protein Nedd8, Neddylin, Neural precursor cell expressed, developmentally down-regulated 8 MGC104393, MGC125896, MGC125897, NED8, 0NEDD 8, Neddylin, Neural precursor cell expressed developmentally down regulated 8, Neural precursor cell expressed developmentally down regulated gene 8, Rub1, ubiquitin like protein Nedd 8, ubiquitin like protein Nedd8.
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
0.5 mg/mL (determined by Bradford assay)
Endotoxin
< 1 EU per 1ug of protein (determined by LAL method)
Purity
> 95% by SDS-PAGE
Molecular Weight
12.8 kDa (113aa) confirmed by MALDI-TOF
Additionnal Information
NEDD8, Neural precursor cell expressed developmentally down-regulated 8, ubiquitin-like protein Nedd8, Neddylin, Neural precursor cell expressed, developmentally down-regulated 8 MGC104393, MGC125896, MGC125897, NED8, 0NEDD 8, Neddylin, Neural precursor cell expressed developmentally down regulated 8, Neural precursor cell expressed developmentally down regulated gene 8, Rub1, ubiquitin like protein Nedd 8, ubiquitin like protein Nedd8., NED0905-10 µg, NED0905-20 µg, NED0905-50 µg, NED0905-100 µg, NED0905-250 µg, NED0905-500 µg, NED0905-1 mg, NED0905-10, NED0905-20, NED0905-50, NED0905-100, NED0905-250, NED0905-500, NED0905-1
References & Citations
Wu K., et al. (2002) J Biol Chem. 277 (1) : 516-27; ; Hori T., et al. (1999) Oncogene. 18 (48) : 6829-34;
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 0.5mM DTT, 50 mM NaCl, 10% glycerol
Scientific Category
Ubiquitination
NCBI Accession Number
NP_006147
Uniprot Accession Number
Q15843
Species
Human
AA Sequence
MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSHMLI KVKTLTGKEI EIDIEPTDKV ERIKERVEEK EGIPPQQQRL IYSGKQMNDE KTAADYKILG GSVLHLVLAL RGG

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