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Recombinant human Vitronectin protein

CAT: 0112-ATGP4165-100Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0112-ATGP4165-100Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Vitronectin, also known VTN, is a member of the pexin family. It is a cell adhesion and spreading factor found in serum and tissues. This protein interacts with glycosaminoglycans and proteoglycans and is recognized by certain members of the integrin family and serves as a cell-to-substrate adhesion molecule. It also contains endogenous cleavage sites such as elastase, thrombin and plasmin. This protein binds multiple ligands, including the soluble vitronectin receptor which affects multi-function. Therefore, it is involved in hemostasis, cell migration, as well as tumor malignancy. Recombinant human Vitronectin protein, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.
Specifications
Human VTN stimulates cell adhesion of the JB16-F1 mouse melanoma cells. This effect is more to 50%.
Product Name Alternative
VTN, VN, S-protein, Serum-spreading factor, V75, Vitronectin V65 subunit, Vitronectin V10 subunit, Somatomedin-B, Somatomedin B, Complement S-protein
Expression System
Baculovirus
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE, Bioactivity
Concentration
0.25 mg/mL (determined by Bradford assay)
Endotoxin
< 0.1 EU per 1ug of protein (determined by LAL method)
Purity
> 90% by SDS-PAGE
Bioactivity
Measured by the ability of the immobilized protein to support the adhesion of B16-F1 mouse melanoma cells. When cells are added to human VTN coated plates 5 µg/mL. This effect is more to 50%.
Molecular Weight
53.3 kDa (468aa)
Additionnal Information
Vitronectin, VitronectinVitronectin, VTN, V75, VN, VNT, ATGP3849-10 µg, ATGP3849-20 µg, ATGP3849-50 µg, ATGP3849-100 µg, ATGP3849-250 µg, ATGP3849-500 µg, ATGP3849-1 mg, ATGP3849-10, ATGP3849-20, ATGP3849-50, ATGP3849-100, ATGP3849-250, ATGP3849-500, ATGP3849-1, ATGP4165-10 µg, ATGP4165-20 µg, ATGP4165-50 µg, ATGP4165-100 µg, ATGP4165-250 µg, ATGP4165-500 µg, ATGP4165-1 mg, ATGP4165-010, ATGP4165-020, ATGP4165-050, ATGP4165-100, ATGP4165-250, ATGP4165-500, ATGP4165-01M
References & Citations
Yang XP., et al, (2016) Cancer Biomark. 17:271-279.; ; Min SK., et al, (2017) Cell Death Differ. 25:268-281.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol
Scientific Category
Cardiovascular
NCBI Accession Number
NP_000629.3
Uniprot Accession Number
P04004
Species
Human
N Terminal Sequence
Ala
AA Sequence
DQESCKG RCTEGFNVDK KCQCDELCSY YQSCCTDYTA ECKPQVTRGD VFTMPEDEYT VYDDGEEKNN ATVHEQVGGP SLTSDLQAQS KGNPEQTPVL KPEEEAPAPE VGASKPEGID SRPETLHPGR PQPPAEEELC SGKPFDAFTD LKNGSLFAFR GQYCYELDEK AVRPGYPKLI RDVWGIEGPI DAAFTRINCQ GKTYLFKGSQ YWRFEDGVLD PDYPRNISDG FDGIPDNVDA ALALPAHSYS GRERVYFFKG KQYWEYQFQH QPSQEECEGS SLSAVFEHFA MMQRDSWEDI FELLFWGRTS AGTRQPQFIS RDWHGVPGQV DAAMAGRIYI SGMAPRPSLA KKQRFRHRNR KGYRSQRGHS RGRNQNSRRP SRATWLSLFS SEESNLGANN YDDYRMDWLV PATCEPIQSV FFFSGDKYYR VNLRTRRVDT VDPPYPRSIA QYWLGCPAPG HL

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