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Recombinant Human Osteocrin protein

CAT: 0112-ATGP4150-250Size: 250 µgDry Ice: NoHazardous: No
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CAT#:0112-ATGP4150-250Size:250 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Osteocrin, also known as Musclin, shows a well conserved homology with members of the natriuretic peptide (NP) family. It is a secreted protein that is expressed in muscle and bone. Based on similarities with NPs, Osteocrin could interact with the NP clearance receptors, importantly increasing CNP which has been shown to stimulate endochondral ossification and elongate bones. It is represents a novel, unique vitamin D-regulated bone-specific. Recombinant human Osteocrin, fused to His-tag at C-terminus, was expressed in HEK 293 cell and purified by using conventional chromatography techniques.
Specifications
Human NPRC is coated at 2 µg/mL (100 ul/well) can bind Human OSTN. The ED50 range ≤ 20 ng/mL.
Product Name Alternative
Osteocrin, MUSCLIN, OSTN
Expression System
HEK293
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE, Bioactivity
Concentration
0.5 mg/mL (determined by Bradford assay)
Endotoxin
< 1 EU per 1ug of protein (determined by LAL method)
Purity
> 95% by SDS-PAGE
Bioactivity
Measured by its binding ability in a functional ELISA with Human NPRC. The ED50 range ≤ 20 ng/mL.
Molecular Weight
12.5kDa (112aa)
Additionnal Information
ATGP4150-10 µg, ATGP4150-20 µg, ATGP4150-50 µg, ATGP4150-100 µg, ATGP4150-250 µg, ATGP4150-500 µg, ATGP4150-1 mg, ATGP4150, ATGP4150-020, ATGP4150-050, ATGP4150-100, ATGP4150-250, ATGP4150-500, ATGP4150-01M
References & Citations
Thomas, G., et al, (2003) J. Biol. Chem. 278:50563–50571.; ; Nishizawa H., et al, (2004) J Biol Chem. 279:19391-19395.; ; Pierre Moffatt., et al, (2007) J Biol Chem. 282:36454-36462.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol
Scientific Category
Stem cell
NCBI Accession Number
NP_937827.1
Uniprot Accession Number
P61366
Species
Human
N Terminal Sequence
Val 19

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