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Recombinant mouse IGFBP-2 protein

CAT: 0112-ATGP4144-020Size: 20 µgDry Ice: NoHazardous: No
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CAT#:0112-ATGP4144-020Size:20 µg
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Description
IGFBP-2, also known as insulin-like growth factor binding protein 2, is a member of IGFBP superfamily. IGFBPs modulate the biological activities of IGF proteins and have a high affinity for IGFs. IGFBPs are not merely carrier proteins for IGFs, but hold a central position in IGF ligand-receptor interactions through influences on both the bioavailability and distribution of IGFs in the extracellular environment. During development, IGFBP-2 is expressed in a number of tissues. The highest expression level is found in the central nervous system. In adults, high expression levels are also detected in the central nervous system and in a number of reproductive tissues.This protein binds preferentially to IGF-2, exhibiting a 2 - 10 fold higher affinity for IGF-2 than for IGF-1. Also, it is overexpressed in many malignancies and is often correlated with an increasingly malignant status of the tumor, pointing to the potential involvement of IGFBP-2 in tumorigenesis. Recombinant mouse IGFBP-2, fused to His-tag at C-terminus, was expressed in HEK293 cell and purified by using conventional chromatography techniques.
Specifications
Mouse IGFBP-2 inhibit proliferation using MCF-7 human breast cancer cells in the presence of Mouse IGF-2. The ED50 range ≤ 0.7 µg/mL.
Product Name Alternative
Insulin-like growth factor binding protein 2 isoform 1, insulin-like growth factor binding protein 2, IBP-2, Igfbp-2, mIGFBP-2, IGF-binding protein 2, Igfbp2
Expression System
HEK293
Antigen Species
Mouse
Tag
His-Tag
Applications
SDS-PAGE, Bioactivity
Concentration
1 mg/mL (determined by Absorbance at 280 nm)
Endotoxin
< 1 EU per 1ug of protein (determined by LAL method)
Purity
> 85% by SDS-PAGE
Bioactivity
Measured by its ability to inhibit proliferation using MCF-7 human breast cancer cells in the presence of Mouse IGF-2. The ED50 range ≤ 0.7 µg/mL.
Molecular Weight
30.3kDa (277aa)
Additionnal Information
ATGP4144-10 µg, ATGP4144-20 µg, ATGP4144-50 µg, ATGP4144-100 µg, ATGP4144-250 µg, ATGP4144-500 µg, ATGP4144-1 mg, ATGP4144, ATGP4144-020, ATGP4144-050, ATGP4144-100, ATGP4144-250, ATGP4144-500, ATGP4144-01M
References & Citations
Yoshiyuki H., et al, (1994) Cellular Physiology. 158:444-450. ; ; Agarwal N., et al, (1991) Exp Eye Res. 52:549-561.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol
Scientific Category
Signal Transduction, Hormones & Cytokines
NCBI Accession Number
NP_032368.2
Uniprot Accession Number
P47877
Species
Mouse
N Terminal Sequence
Glu35

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