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Recombinant human RNASE2 protein

CAT: 0112-ATGP4065-010Size: 10 µgDry Ice: NoHazardous: No
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CAT#:0112-ATGP4065-010Size:10 µg
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Description
RNASE2, is a non-secretory ribonuclease that belongs to the pancreatic ribonuclease family, a subset of the ribonuclease A superfamily. The protein is found in eosinophil granulocytes and closely related to the eosinophil cationic protein (RNASE3) from which it diverged 50 million years ago after the split between the old world and the new world monkeys. It is relatively neutral and has cytotoxic properties. It may generate host defense via roles in promoting leukocyte activation, maturation, and chemotaxis. It has also been studied in the context of defense against pathogen infection in mammals. Recombinant human RNASE2, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.
Product Name Alternative
Ribonuclease A family member 2, EDN, RAF3, RNS2, non-secretory ribonuclease, Eosinophil-derived neurotoxin, RNase UpI-2, Ribonuclease 2, RNase 2, Ribonuclease US
Expression System
Baculovirus
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
1 mg/mL (determined by Absorbance at 280 nm)
Endotoxin
< 1 EU per 1ug of protein (determined by LAL method)
Purity
> 90% by SDS - PAGE
Molecular Weight
16.5kDa (143aa)
Additionnal Information
ATGP4065-10 µg, ATGP4065-20 µg, ATGP4065-50 µg, ATGP4065-100 µg, ATGP4065-250 µg, ATGP4065-500 µg, ATGP4065-1 mg, ATGP4065-10, ATGP4065-20, ATGP4065-50, ATGP4065-100, ATGP4065-250, ATGP4065-500, ATGP4065-1
References & Citations
Rosenberg HF., et al, (2015) Int J Mol Sci. 14:15442-15455. ; ; Levin AM., et al, (2019) J Allergy Clin Immunol. 143:1791-1802.; ; Ostendorf T., et al, (2020) Immunity. 52:591-605.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid. In Phosphate-Buffered Saline (pH 7.4) containing 20% glycerol
Scientific Category
Epigenomics (Transcription & Translation)
NCBI Accession Number
NP_002925.1
Uniprot Accession Number
P10153
Species
Human
N Terminal Sequence
Ala
AA Sequence
KPPQFTW AQWFETQHIN MTSQQCTNAM QVINNYQRRC KNQNTFLLTT FANVVNVCGN PNMTCPSNKT RKNCHHSGSQ VPLIHCNLTT PSPQNISNCR YAQTPANMFY IVACDNRDQR RDPPQYPVVP VHLDRII

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