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Recombinant mouse ACE-2 protein

CAT: 0112-ATGP4014-100Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0112-ATGP4014-100Size:100 µg
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Description
ACE-2, also known as angiotensin-converting enzyme 2, is an integral membrane protein and a zinc metalloprotease of the ACE family that also includes somatic and germinal ACE. It cleaves angiotensin 1 to angiotensin 1-9 and angiotensin 2 to angiotensin 1-7 as a carboxypeptidase. It may be an important regulator of heart function and have a protective role in acute lung injury. Also, it is a key SARS-CoV Spike protein receptor in vivo. Recombinant mouse ACE-2, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.
Product Name Alternative
Angiotensin-converting enzyme 2, ACE-related carboxypeptidase, Processed Angiotensin-converting enzyme 2, ACE2, 2010305L05Rik
Expression System
Baculovirus
Antigen Species
Mouse
Tag
His-Tag
Applications
SDS-PAGE, Enzyme Activity
Concentration
1 mg/mL (determined by absorbance at 280 nm)
Endotoxin
< 1 EU per 1ug of protein (determined by LAL method)
Purity
> 95% by SDS-PAGE
Bioactivity
Specific activity is > 200 pmol/min/ug, and is defined as the amount of enzyme that hydrolysis 1.0 pmole of Mca-YVADAPK (Dnp) -OH per minute at pH 7.5, at 25C.
Molecular Weight
84.5 kDa (731aa)
Additionnal Information
ATGP3288, ATGP4014-10 µg, ATGP4014-20 µg, ATGP4014-50 µg, ATGP4014-100 µg, ATGP4014-250 µg, ATGP4014-500 µg, ATGP4014-1 mg, ATGP4014-10, ATGP4014-20, ATGP4014-50, ATGP4014-100, ATGP4014-250, ATGP4014-500, ATGP4014-1, ATGP4014-10 µg, ATGP4014-20 µg, ATGP4014-50 µg, ATGP4014-100 µg, ATGP4014-250 µg, ATGP4014-500 µg, ATGP4014-1 mg, ATGP4014-10, ATGP4014-20, ATGP4014-50, ATGP4014-100, ATGP4014-250, ATGP4014-500, ATGP4014-1
References & Citations
Kuba K., et al. (2005) Nature Med. 11:875-879.; ; Ima Y., et al. (2005) Nature 436:112-116.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol
Scientific Category
Enzymes & Proteases
NCBI Accession Number
NP_081562.2
Uniprot Accession Number
Q8R0I0
Species
Mouse
N Terminal Sequence
Gln18

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