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Recombinant human IL-4 protein

CAT: 0112-ATGP3983-250Size: 250 µgDry Ice: NoHazardous: No
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CAT#:0112-ATGP3983-250Size:250 µg
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Description
IL-4 is a multi-functional cytokine that plays a critical role in the regulation of immune responses. It induces differentiation of naive helper T cells to Th2 cells. Upon activation by IL-4, Th2 cells subsequently produce additional IL-4 in a positive feedback loop. IL-4 is produced primarily by mast cells, Th2 cells, eosinophils and basophils. It is closely related and has functions similar to interleukin 13. This protein has many biological roles, including the stimulation of activated B-cell and T-cell proliferation, and the differentiation of B cells into plasma cells. It is a key regulator in humoral and adaptive immunity. IL-4 plays a dominant role in the development of allergic inflammation and asthma. Also, it is crucial in the development of allergic airway inflammation originates. Recombinant human IL-4, fused to His-tag at C-terminus, was expressed in HEK293 cell and purified by using conventional chromatography techniques.
Specifications
Human IL-4 in a cell proliferation assay using TF-1 human erythroleukemic cell. The ED50 range ≤ 0.5 ng/mL.
Product Name Alternative
Pitrakinra, MGC79402, Lymphocyte stimulatory factor 1, Interleukin-4 isoform 1, Interleukin 4, IL-4, BSF1, Binetrakin, BCGF1, B-cell stimulatory factor 1, B-cell growth factor 1, BCDF
Expression System
HEK293
Antigen Species
Mouse
Tag
His-Tag
Applications
SDS-PAGE, Bioactivity
Concentration
0.5 mg/mL (determined by Absorbance at 280 nm)
Endotoxin
< 1 EU per 1ug of protein (determined by LAL method)
Purity
> 90% by SDS - PAGE
Bioactivity
Measured in a cell proliferation assay using TF-1 human erythroleukemic cell. The ED50 range ≤ 0.5 ng/mL.
Molecular Weight
16.1kDa (139aa)
Additionnal Information
Pitrakinra, Pitrakinara, MGC79402, Lymphocyte stimulatory factor 1, Interleukin-4 isoform 1, Interleukin-4, Interleukin4, Interleukin 4 isoform 1, Interleukin 4, IL-4, IL4, IL 4, BSF-1, BSF1, BSF 1, Binetrakin, BCGF-1, BCGF1, BCGF 1, B-cell stimulatory factor 1, B-cell growth factor 1, BCDF, B cell stimulatory factor 1, B cell growth factor 1, ATGP3983-10 µg, ATGP3983-20 µg, ATGP3983-50 µg, ATGP3983-100 µg, ATGP3983-250 µg, ATGP3983-500 µg, ATGP3983-1 mg, ATGP3983-010, ATGP3983-020, ATGP3983-050, ATGP3983-100, ATGP3983-250, ATGP3983-500, ATGP3983-01M
References & Citations
Bhattarai P., et al, (2016) Cell Reports. 17: 941–948.; ; Cheng Ho ., et al, (2016) Adv Exp Med Biol. 941:31-77.; ; Marsha Wills-Karp., et al, (2008) Sci Signal. 1:pe55.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid. In Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol
Scientific Category
Immunology, Hormones & Cytokines
NCBI Accession Number
NP_000580
Uniprot Accession Number
P05112
Species
Mouse
N Terminal Sequence
Asp
AA Sequence
HKCDIT LQEIIKTLNS LTEQKTLCTE LTVTDIFAAS KNTTEKETFC RAATVLRQFY SHHEKDTRCL GATAQQFHRH KQLIRFLKRL DRNLWGLAGL NSCPVKEANQ STLENFLERL KTIMREKYSK CSS

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