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Recombinant mouse CD30/TNFRSF8 protein

CAT: 0112-ATGP3949-500Size: 500 µgDry Ice: NoHazardous: No
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CAT#:0112-ATGP3949-500Size:500 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CD30/TNFRSF8, also known as TNF Receptor Superfamily Member 8, is a member of TNF-receptor superfamily. This receptor is expressed by activated, but not by resting, T and B cells. TRAF2 and TRAF5 can interact with this receptor and mediate the signal transduction that leads to the activation of NF-kappaB. This receptor is a positive regulator of apoptosis and also has been shown to limit the proliferative potential of autoreactive CD8 effector T cells and protect the body against autoimmunity. CD30 contributes to thymic negative selection by inducing the apoptotic cell death of CD4+CD8+ T cells. In B cells, CD30 ligation promotes cellular proliferation and antibody production in addition to the expression of CXCR4, CCL3, and CCL5. Recombinant mouse CD30/TNFRSF8 protein, fused to hIgG-His tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.
Product Name Alternative
Tumor necrosis factor receptor superfamily member 8, CD30L receptor, Lymphocyte activation antigen CD30, CD_antigen, CD30, Ki-1, D1S166E, ki
Expression System
Baculovirus
Antigen Species
Mouse
Tag
HIgG-His-Tag
Applications
SDS-PAGE
Concentration
1 mg/mL (determined by Absorbance at 280 nm)
Endotoxin
< 1 EU per 1ug of protein (determined by LAL method)
Purity
> 90% by SDS-PAGE
Molecular Weight
52.2kDa (479aa)
Additionnal Information
, ATGP3949-10 µg, ATGP3949-20 µg, ATGP3949-50 µg, ATGP3949-100 µg, ATGP3949-250 µg, ATGP3949-500 µg, ATGP3949-1 mg, ATGP3949-10, ATGP3949-20, ATGP3949-50, ATGP3949-100, ATGP3949-250, ATGP3949-500, ATGP3949-1
References & Citations
So T, Ishii N. (2019) Adv Exp Med Biol. 1189:53-84.; ; Jeon SH, et al, (2015) Acta Odontol Scand. 73 (8) :588-594.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol
Scientific Category
Immunology
NCBI Accession Number
NP_033427
Uniprot Accession Number
Q60846
Species
Mouse
N Terminal Sequence
Phe 19

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