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Recombinant human MBL protein

CAT: 0112-ATGP3749-100Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0112-ATGP3749-100Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
MBL2, also known as mannose-binding protein C, belongs to the class of collectins in the C-type lectin superfamily. It is a lectin that is instrumental in innate immunity via the lectin pathway. It recognizes carbohydrate patterns, found on the surface of a large number of pathogenic micro-organisms, including bacteria, viruses, protozoa and fungi. It It binds senescent and apoptotic cells and enhances engulfment of whole, intact apoptotic cells, as well as cell debris by phagocytes. This protein has recently been found to play a role in development of type 1 diabetes and gestational diabetes mellitus. Also, mutant MBL2 haplotypes have been linked to disease progression and response to therapy in HCV infection. Recombinant human MBL2, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.
Product Name Alternative
Mannose binding lectin 2, MBL, Collectin 1, Mannose-binding protein, COLEC1, MBP-C, MBP1, MBP
Expression System
Baculovirus
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
1 mg/mL (determined by absorbance at 280 nm)
Endotoxin
< 1 EU per 1ug of protein (determined by LAL method)
Purity
> 90% by SDS-PAGE
Molecular Weight
25.1 kDa (237aa)
Additionnal Information
MBL2, Mannose-binding protein C, MBL2, COLEC1, HSMBPC, MBL, MBL2D, MBP, MBP-C, MBP1, MBPD, ATGP3749-10 µg, ATGP3749-20 µg, ATGP3749-50 µg, ATGP3749-100 µg, ATGP3749-250 µg, ATGP3749-500 µg, ATGP3749-1 mg, ATGP3749-10, ATGP3749-20, ATGP3749-50, ATGP3749-100, ATGP3749-250, ATGP3749-500, ATGP3749-1
References & Citations
Tomaiuolo R., et al. (2012) Aging Cell. 11:394-400.; ; Stuart LM., et al. (2005) J Immunol. 174:3220-3226.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol
Scientific Category
Immunology
NCBI Accession Number
NP_000233.1
Uniprot Accession Number
P11226
Species
Human
N Terminal Sequence
Ala
AA Sequence
ETVTCED AQKTCPAVIA CSSPGINGFP GKDGRDGTKG EKGEPGQGLR GLQGPPGKLG PPGNPGPSGS PGPKGQKGDP GKSPDGDSSL AASERKALQT EMARIKKWLT FSLGKQVGNK FFLTNGEIMT FEKVKALCVK FQASVATPRN AAENGAIQNL IKEEAFLGIT DEKTEGQFVD LTGNRLTYTN WNEGEPNNAG SDEDCVLLLK NGQWNDVPCS TSHLAVCEFP I

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