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Recombinant human CD55/DAF protein

CAT: 0112-ATGP3730-010Size: 10 µgDry Ice: NoHazardous: No
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CAT#:0112-ATGP3730-010Size:10 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CD55, also known as complement decay-accelerating factor isoform 1, is a membrane protein that attaches to cell membrane via a glycophosphatidylinositol (GPI) anchor. It contains four complement control protein repeats (CCPs) with a single N-linked glycan positioned between CCPs 1 and 2. It regulates the complement system on the cell surface. It is used as a receptor by some coxsackieviruses and other enteroviruses. It is broadly distributed among hematopoietic and non-hematopoietic cells. It is a determinant for the Cromer blood group system. It plays a role promotion of tumorigenesis, decrease of complement mediated tumor cell lysis, autocrine loops for cell rescue and evasion of apoptosis, neoangiogenesis, invasiveness, cell motility. Recombinant human CD55, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.
Product Name Alternative
Complement decay-accelerating factor isoform 1, CD55, CHAPLE, CR, CROM, DAF, TC
Expression System
Baculovirus
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
0.5 mg/mL (determined by BCA assay)
Endotoxin
< 1 EU per 1ug of protein (determined by LAL method)
Purity
> 95% by SDS-PAGE
Molecular Weight
36 kDa (328aa)
Additionnal Information
CD55, DAF, Complement decay-accelerating factor isoform 1, CD55, CHAPLE, CR, CROM, DAF, TC, ATGP3730-10 µg, ATGP3730-20 µg, ATGP3730-50 µg, ATGP3730-100 µg, ATGP3730-250 µg, ATGP3730-500 µg, ATGP3730-1 mg, ATGP3730-10, ATGP3730-20, ATGP3730-50, ATGP3730-100, ATGP3730-250, ATGP3730-500, ATGP3730-1
References & Citations
Ozen A., et al. (2017) N Engl J Med. 377:52-61.; ; Brodbeck WG., et al. (2000) Immunology. 101:104-111.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol
Scientific Category
Immunology
NCBI Accession Number
NP_000565
Uniprot Accession Number
P08174
Species
Human
N Terminal Sequence
Ala
AA Sequence
ADPDCGLPPD VPNAQPALEG RTSFPEDTVI TYKCEESFVK IPGEKDSVIC LKGSQWSDIE EFCNRSCEVP TRLNSASLKQ PYITQNYFPV GTVVEYECRP GYRREPSLSP KLTCLQNLKW STAVEFCKKK SCPNPGEIRN GQIDVPGGIL FGATISFSCN TGYKLFGSTS SFCLISGSSV QWSDPLPECR EIYCPAPPQI DNGIIQGERD HYGYRQSVTY ACNKGFTMIG EHSIYCTVNN DEGEWSGPPP ECRGKSLTSK VPPTVQKPTT VNVPTTEVSP TSQKTTTKTT TPNAQATRST PVSRTTKHFH ETTPNKGSGT TSHHHHHH

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