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Recombinant human Epigen protein

CAT: 0112-ATGP3682-050Size: 50 µgDry Ice: NoHazardous: No
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CAT#:0112-ATGP3682-050Size:50 µg
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Description
EPGN, also known as epigen isoform 1, is a novel member of the epidermal growth factor superfamily. It is the last ligand of ErbB receptors and reveals intricate relationships between affinity and mitogenicity. It stimulated the proliferation of HaCaT cells, and this proliferation was blocked by an antibody to the extracellular domain of the receptor tyrosine kinase c-erbB-1. It also may constitute a novel molecular target for wound-healing therapy with its ability to promote the growth of epithelial cells. It has been reported to have high mitogenic activity but low affinity for its receptor. It has been reported in cancer specimens of the breast, bladder, and prostate. Recombinant human EPGN, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.
Product Name Alternative
Epigen isoform 1, EPGN, ALGV3072, EPG, PRO9904
Expression System
Baculovirus
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
0.5 mg/mL (determined by absorbance at 280 nm)
Endotoxin
< 1 EU per 1ug of protein (determined by LAL method)
Purity
> 90% by SDS-PAGE
Molecular Weight
10.8 kDa (97aa)
Additionnal Information
Epigen, Epigen isoform 1, EPGN, ALGV3072, EPG, PRO9904, ATGP3682-10 µg, ATGP3682-20 µg, ATGP3682-50 µg, ATGP3682-100 µg, ATGP3682-250 µg, ATGP3682-500 µg, ATGP3682-1 mg, ATGP3682-10, ATGP3682-20, ATGP3682-50, ATGP3682-100, ATGP3682-250, ATGP3682-500, ATGP3682-1
References & Citations
Kochupurakkal BS., et al. (2005) J Biol Chem. 280:8503-8512.; ; Strachan L., et al. (2001) J Biol Chem. 276:18265-18271.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol
Scientific Category
Signal Transduction
NCBI Accession Number
NP_001257918
Uniprot Accession Number
Q6UW88
Species
Human
N Terminal Sequence
Ala
AA Sequence
ADPAAVTVTP PITAQQGNWT VNKTEADNIE GPIALKFSHL CLEDHNSYCI NGACAFHHEL EKAICRCFTG YTGERCEHLT LTSYAVDSYE KHHHHHH

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