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Recombinant human UMPS protein

CAT: 0112-ATGP3659-010Size: 10 µgDry Ice: NoHazardous: No
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CAT#:0112-ATGP3659-010Size:10 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
UMPS, also known as uridine 5'-monophosphate synthase, is a bifunctional enzyme catalyzing the last two steps of de novo pyrimidine biosynthesis. It is an indispensable component in this metabolic pathway and is a target for antimalarial and antitumor drugs. Its expression in colorectal carcinoma tissues is not correlated with the toxicities of 5-FU-based regimen, but It in the normal tissues can help predict the toxicities associated with 5-FU. Recombinant human UMPS, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.
Product Name Alternative
Uridine 5'-monophosphate synthase, UMPS, OPRT
Expression System
Baculovirus
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
0.25 mg/mL (determined by absorbance at 280 nm)
Endotoxin
< 1 EU per 1ug of protein (determined by LAL method)
Purity
> 95% by SDS-PAGE
Molecular Weight
53 kDa (486aa)
Additionnal Information
UMPS, Uridine 5'-monophosphate synthase, UMPS, OPRT, ATGP3659-10 µg, ATGP3659-20 µg, ATGP3659-50 µg, ATGP3659-100 µg, ATGP3659-250 µg, ATGP3659-500 µg, ATGP3659-1 mg, ATGP3659-10, ATGP3659-20, ATGP3659-50, ATGP3659-100, ATGP3659-250, ATGP3659-500, ATGP3659-1
References & Citations
Zhang Y., et al. (2013) J Biol Chem. 288:34746-34754.; ; Dong Q., et al. (2012) Nan Fang Yi Ke Da Xue Xue Bao. 32:1179-1181.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 30% glycerol
Scientific Category
Epigenomics (Transcription & Translation)
NCBI Accession Number
NP_000364.1
Uniprot Accession Number
P11172
Species
Human
N Terminal Sequence
Met1

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