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Recombinant human CD28 protein

CAT: 0112-ATGP3603-100Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0112-ATGP3603-100Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CD28, also known as T-cell-specific surface glycoprotein CD28 isoform 1, is one of the proteins expressed on T cells that provide co-stimulatory signals required for T cell activation and survival. T cell stimulation through CD28 in addition to the T-cell receptor (TCR) can provide a potent signal for the production of various interleukins (IL-6 in particular) . CD28/B7 interaction has been shown to prevent apoptosis of activated T cells via the up-regulation of bcl-XL. It ligation has also been shown to regulate Th1/Th2 differentiation. Recombinant human CD28, fused to hIgG-His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.
Product Name Alternative
T-cell-specific surface glycoprotein CD28 isoform 1, CD28, Tp44
Expression System
Baculovirus
Antigen Species
Human
Tag
HIgG-His-Tag
Applications
SDS-PAGE, Bioactivity
Concentration
1 mg/mL (determined by absorbance at 280 nm)
Endotoxin
< 1 EU per 1ug of protein (determined by LAL method)
Purity
> 90% by SDS-PAGE
Molecular Weight
42.4 kDa (376aa)
Additionnal Information
CD28, ATGP3603-10 µg, ATGP3603-20 µg, ATGP3603-50 µg, ATGP3603-100 µg, ATGP3603-250 µg, ATGP3603-500 µg, ATGP3603-1 mg, ATGP3603-10, ATGP3603-20, ATGP3603-50, ATGP3603-100, ATGP3603-250, ATGP3603-500, ATGP3603-1
References & Citations
Prasad KV., et al. (1994) National Academy. 91: 2834 -2838.; ; Okkenhaug K., et al. (1998) J. Biol. Chem. 273: 21194 -21202.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol
Scientific Category
Immunology
NCBI Accession Number
NP_006130.1
Uniprot Accession Number
P10747
Species
Human
N Terminal Sequence
Ala
AA Sequence
NKILVKQ SPMLVAYDNA VNLSCKYSYN LFSREFRASL HKGLDSAVEV CVVYGNYSQQ LQVYSKTGFN CDGKLGNESV TFYLQNLYVN QTDIYFCKIE VMYPPPYLDN EKSNGTIIHV KGKHLCPSPL FPGPSKP

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