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Recombinant human M-CSF protein

CAT: 0112-ATGP3565-020Size: 20 µgDry Ice: NoHazardous: No
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CAT#:0112-ATGP3565-020Size:20 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CSF1, also known as macrophage colony-stimulating factor 1, is a hematopoietic growth factor that is the primary regulator of the survival, proliferation, differentiation and function of mononuclear phagocytes. It is a four alpha-helical bundle cytokine and its active form is found extracellularly as a disulfide linked homodimer. This protein plays important roles in innate immunity, cancer and inflammatory diseases, including systemic lupus erythematosus, arthritis, atherosclerosis and obesity. In several conditions, activation of macrophages involves a CSF1 autocrine loop. In addition, secreted and cell-surface isoforms of CSF1 can have differential effects in inflammation and immunity. Recombinant human CSF1, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.
Specifications
Human M-CSF stimulates cell proliferation of the M-NFS-60 mouse myelogenous leukemia lymphoblast cells. The ED50 range ≤3 ng/mL.
Product Name Alternative
Macrophage colony-stimulating factor 1, CSF1, M-CSF, MCSF, Lanimostim, ATGP3269
Expression System
Baculovirus
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE, Bioactivity
Concentration
0.25 mg/mL (determined by absorbance at 280 nm)
Endotoxin
< 1 EU per 1ug of protein (determined by LAL method)
Purity
> 95% by SDS-PAGE
Bioactivity
Measured in a cell proliferation assay using M-NFS-60 mouse myelogenous leukemia lymphoblast cells. The ED50 range ≤3 ng/mL.
Molecular Weight
26.1 kDa (231aa)
Additionnal Information
M-CSF, ATGP3565-10 µg, ATGP3565-20 µg, ATGP3565-50 µg, ATGP3565-100 µg, ATGP3565-250 µg, ATGP3565-500 µg, ATGP3565-1 mg, ATGP3565-10, ATGP3565-20, ATGP3565-50, ATGP3565-100, ATGP3565-250, ATGP3565-500, ATGP3565-1
References & Citations
Chitu V., et al. (2006) Curr Opin Immunol. 18 (1) :39-48.; ; Eda H., et al. (2010) Cytokine. 52 (3) :215-220.; ; Tian F., et al. (2013) Oncol. Res. 20 (8) :341-350.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol
Scientific Category
Immunology
NCBI Accession Number
NP_000748
Uniprot Accession Number
P09603
Species
Human
N Terminal Sequence
Glu33

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