Recombinant human CD46 protein

• Description:

  CD46, also known as membrane cofactor protein isoform 14, is a type 1 membrane protein that plays an important inhibitory role in the complement system. It is expressed in white blood cells, platelets, epithelial cells, and fibroblasts. The importance of CD46 to complement regulation is underscored by the observation that genetic loss of CD46 leads to development of atypical hemolytic-uremic syndrome, a disease characterized by uncontrolled complement activation. Recombinant human CD46, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

• Product Name Alternative:

  Membrane cofactor protein isoform 14, CD46, AHUS2, MCP, MIC10, TLX, TRA2.10

• Expression System:

  Baculovirus

• Antigen Species:

  Human

• Tag:

  His-Tag

• Applications:

  SDS-PAGE

• Concentration:

  0.5 mg/mL (determined by absorbance at 280 nm)

• Endotoxin:

  < 1 EU per 1ug of protein (determined by LAL method)

• Purity:

  > 90% by SDS-PAGE

• Molecular Weight:

  32.5 kDa (288aa)

• Additionnal Information:

  CD46, Membrane cofactor protein isoform 14, CD46, AHUS2, MCP, MIC10, TLX, TRA2.10, ATGP3451-10 µg, ATGP3451-20 µg, ATGP3451-50 µg, ATGP3451-100 µg, ATGP3451-250 µg, ATGP3451-500 µg, ATGP3451-1 mg, ATGP3451-10, ATGP3451-20, ATGP3451-50, ATGP3451-100, ATGP3451-250, ATGP3451-500, ATGP3451-1

• References & Citations:

  Lublin DM., et al. (1988) J Exp Med. 168:181-194.; ; Maga TK., et al. (2010) Hum. Mutat. 31:E1445-14460.

• Storage Conditions:

  Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

• Formulation:

  Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

• Scientific Category:

  Immunology

• NCBI Accession Number:

  NP_758860

• Uniprot Accession Number:

  P15529

• Species:

  Human

• N Terminal Sequence:

  Ala

• AA Sequence:

  ADLCEEPPTF EAMELIGKPK PYYEIGERVD YKCKKGYFYI PPLATHTICD RNHTWLPVSD DACYRETCPY IRDPLNGQAV PANGTYEFGY QMHFICNEGY YLIGEEILYC ELKGSVAIWS GKPPICEKVL CTPPPKIKNG KHTFSEVEVF EYLDAVTYSC DPAPGPDPFS LIGESTIYCG DNSVWSRAAP ECKVVKCRFP VVENGKQISG FGKKFYYKAT VMFECDKGFY LDGSDTIVCD SNSTWDPPVP KCLKGPRPTY KPPVSNYPGY PKPEEGILDS LDHHHHHH