Products for Research Use Only

Recombinant human QPCT protein

CAT: 0112-ATGP3153-010Size: 10 µgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0112-ATGP3153-010Size:10 µg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
QPCT, also known as glutaminyl-peptide cyclotransferase, is responsible for the biosynthesis of pyroglutamyl peptides. This protein has a bias against acidic and tryptophan residues adjacent to the N-terminal glutaminyl residue and a lack of importance of chain length after the second residue. It catalyzes N-terminal pyroglutamate formation. In vitro, it catalyzes pyroglutamate formation of N-terminally truncated form of APP amyloid-beta peptides [Glu-3]-beta-amyloid. Recombinant human QPCT, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.
Product Name Alternative
Glutaminyl-peptide cyclotransferase, GCT, QC, sQC
Expression System
Baculovirus
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
0.5 mg/mL (determined by absorbance at 280 nm)
Endotoxin
< 1 EU per 1ug of protein (determined by LAL method)
Purity
> 90% by SDS-PAGE
Molecular Weight
38.7 kDa (339aa)
Additionnal Information
QPCT, Glutaminyl-peptide cyclotransferase, GCT, QC, sQC, ATGP3153-10 µg, ATGP3153-20 µg, ATGP3153-50 µg, ATGP3153-100 µg, ATGP3153-250 µg, ATGP3153-500 µg, ATGP3153-1 mg, ATGP3153-10, ATGP3153-20, ATGP3153-50, ATGP3153-100, ATGP3153-250, ATGP3153-500, ATGP3153-1
References & Citations
Schilling S. et al., (2004) FEBS Lett. 563:191-196.; ; Huang K.F. et al., (2011) J. Biol. Chem. 286:12439-12449.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol
Scientific Category
Neuroscience
NCBI Accession Number
NP_036545
Uniprot Accession Number
Q16769
Species
Human
AA Sequence
VSPSASAWPE EKNYHQPAIL NSSALRQIAE GTSISEMWQN DLQPLLIERY PGSPGSYAAR QHIMQRIQRL QADWVLEIDT FLSQTPYGYR SFSNIISTLN PTAKRHLVLA CHYDSKYFSH WNNRVFVGAT DSAVPCAMML ELARALDKKL LSLKTVSDSK PDLSLQLIFF DGEEAFLHWS PQDSLYGSRH LAAKMASTPH PPGARGTSQL HGMDLLVLLD LIGAPNPTFP NFFPNSARWF ERLQAIEHEL HELGLLKDHS LEGRYFQNYS YGGVIQDDHI PFLRRGVPVL HLIPSPFPEV WHTMDDNEEN LDESTIDNLN KILQVFVLEY LHLHHHHHH