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Recombinant human Cystatin D protein

CAT: 0112-ATGP3122-050Size: 50 µgDry Ice: NoHazardous: No
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CAT#:0112-ATGP3122-050Size:50 µg
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Description
CST5, also known as Cystatin-D, is a novel member of the cystatin superfamily. The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions. Two alleles of the cystatin D gene (CST5), encoding protein variants with either Cys or Arg as residue 26 in their 122-residue polypeptide chains, are present in the population. Recombinant human CST5, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.
Specifications
The IC50 value is < 2.0 nm. The inhibitory function of Cystatin 5 on protease activity of papain was measured by a fluorometric assay using Z-FR-AMC at pH 7.5 at 25C.
Product Name Alternative
Cystatin-D
Expression System
Baculovirus
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE, Enzyme Activity
Concentration
0.5 mg/mL (determined by absorbance at 280 nm)
Endotoxin
< 1 EU per 1ug of protein (determined by LAL method)
Purity
> 90% by SDS-PAGE
Bioactivity
The IC50 value is < 2.0 nm. The inhibitory function of Cystatin 5 on protease activity of papain was measured by a fluorometric assay using Z-FR-AMC at pH 7.5 at 25C.
Molecular Weight
14.36 kDa (123aa)
Additionnal Information
Cystatin D, Cystatin-D, ATGP3122-10 µg, ATGP3122-20 µg, ATGP3122-50 µg, ATGP3122-100 µg, ATGP3122-250 µg, ATGP3122-500 µg, ATGP3122-1 mg, ATGP3122-10, ATGP3122-20, ATGP3122-50, ATGP3122-100, ATGP3122-250, ATGP3122-500, ATGP3122-1
References & Citations
Balbin M. et al. (1994) J Biol Chem. 269:23156-23162.; ; Alvarez-Fernandez M. et al. (2005) J Biol Chem. 280:18221-18228.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol
Scientific Category
Protease inhibitors
NCBI Accession Number
NP_001891.2
Uniprot Accession Number
P28325
Species
Human

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