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Recombinant human IMPAD1 protein

CAT: 0112-ATGP2986-010Size: 10 µgDry Ice: NoHazardous: No
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CAT#:0112-ATGP2986-010Size:10 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
IMPAD1, also known as Inositol monophosphatase 3, is a member of the inositol monophosphatase family. IMPAD1 is localized to the Golgi apparatus and catalyzes the hydrolysis of phosphoadenosine phosphate (PAP) to adenosine monophosphate (AMP) . Mutations in this gene are a cause of GRAPP type chondrodysplasia with joint dislocations, and a pseudogene of this gene is located on the long arm of chromosome 1. Recombinant human IMPAD1 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by conventional chromatography, after refolding of the isolated inclusion bodies in a renaturation buffer.
Specifications
Specific acitivty > 3300 pmol/min/ug, its ability to dephosphorylate adenosine 3'5'-diphosphate sodium slat at pH 7.5, 25C.
Product Name Alternative
Inositol monophosphatase 3, GPAPP, IMP 3, IMP-3, IMPA3
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
Enzyme Activity, SDS-PAGE
Concentration
0.25 mg/mL (determined by Bradford assay)
Purity
> 90% by SDS-PAGE
Bioactivity
Specific acitivty > 3300pmol/min/ug, its ability to dephosphorylate adenosine 3'5'-diphosphate sodium slat at pH 7.5, 25C.
Molecular Weight
37.6 kDa (349aa) confirmed by MALDI-TOF
Additionnal Information
IMPAD1, Inositol monophosphatase 3, GPAPP, IMP 3, IMP-3, IMPA3, ATGP2986-10 µg, ATGP2986-20 µg, ATGP2986-50 µg, ATGP2986-100 µg, ATGP2986-250 µg, ATGP2986-500 µg, ATGP2986-1 mg, ATGP2986-10, ATGP2986-20, ATGP2986-50, ATGP2986-100, ATGP2986-250, ATGP2986-500, ATGP2986-1
References & Citations
Vissers L E., et al. (2011) Am J Hum Genet. 88:608-615. ; ; Kalujnaia S., et al. (2010) FASEB J. 24:3981-3991.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. Phosphate-Buffered Saline (pH 7.4)
Scientific Category
Cardiovascular
NCBI Accession Number
NP_060283
Uniprot Accession Number
Q9NX62
Species
Human
AA Sequence
MGSSHHHHHH SSGLVPRGSH MGSGRFSLFG LGGEPGGGAA GPAAAADGGT VDLREMLAVS VLAAVRGGDE VRRVRESNVL HEKSKGKTRE GAEDKMTSGD VLSNRKMFYL LKTAFPSVQI NTEEHVDAAD QEVILWDHKI PEDILKEVTT PKEVPAESVT VWIDPLDATQ EYTEDLRKYV TTMVCVAVNG KPMLGVIHKP FSEYTAWAMV DGGSNVKARS SYNEKTPRIV VSRSHSGMVK QVALQTFGNQ TTIIPAGGAG YKVLALLDVP DKSQEKADLY IHVTYIKKWD ICAGNAILKA LGGHMTTLSG EEISYTGSDG IEGGLLASIR MNHQALVRKL PDLEKTGHK

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