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Recombinant human PICK1 protein

CAT: 0112-ATGP2927-250Size: 250 µgDry Ice: NoHazardous: No
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CAT#:0112-ATGP2927-250Size:250 µg
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Description
PICK1 contains a PDZ domain, through which it interacts with protein kinase C, alpha (PRKCA) . This protein may function as an adaptor that binds to and organizes the subcellular localization of a variety of membrane proteins. It has been shown to interact with multiple glutamate receptor subtypes, monoamine plasma membrane transporters, as well as non-voltage gated sodium channels, and may target PRKCA to these membrane proteins and thus regulate their distribution and function. PICK1 has also been found to act as an anchoring protein that specifically targets PRKCA to mitochondria in a ligand-specific manner. Recombinant human PICK1 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.
Product Name Alternative
PRKCA-binding protein, Protein interacting with PRKCA 1, PICK, PRKCABP
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
0.25 mg/mL (determined by Bradford assay)
Purity
> 85% by SDS-PAGE
Molecular Weight
49 kDa (438aa) confirmed by MALDI-TOF (Molecular weight on SDS-PAGE will appear higher)
Additionnal Information
PICK1, PRKCA-binding protein, Protein interacting with PRKCA 1, PICK, PRKCABP, ATGP2927-10 µg, ATGP2927-20 µg, ATGP2927-50 µg, ATGP2927-100 µg, ATGP2927-250 µg, ATGP2927-500 µg, ATGP2927-1 mg, ATGP2927-10, ATGP2927-20, ATGP2927-50, ATGP2927-100, ATGP2927-250, ATGP2927-500, ATGP2927-1
References & Citations
Shao X., et al. (2010) Neurochem. Int. 56:962-970.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 30% glycerol, 1mM DTT
Scientific Category
Neuroscience
NCBI Accession Number
NP_001034673
Uniprot Accession Number
Q9NRD5
Species
Human
AA Sequence
MFADLDY DIEEDKLGIP TVPGKVTLQK DAQNLIGISI GGGAQYCPCL YIVQVFDNTP AALDGTVAAG DEITGVNGRS IKGKTKVEVA KMIQEVKGEV TIHYNKLQAD PKQGMSLDIV LKKVKHRLVE NMSSGTADAL GLSRAILCND GLVKRLEELE RTAELYKGMT EHTKNLLRAF YELSQTHRAF GDVFSVIGVR EPQPAASEAF VKFADAHRSI EKFGIRLLKT IKPMLTDLNT YLNKAIPDTR LTIKKYLDVK FEYLSYCLKV KEMDDEEYSC IALGEPLYRV STGNYEYRLI LRCRQEARAR FSQMRKDVLE KMELLDQKHV QDIVFQLQRL VSTMSKYYND CYAVLRDADV FPIEVDLAHT TLAYGLNQEE FTDGEEEEEE EDTAAGEPSR DTRGAAGPLD KGGSWCDS