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Recombinant human Properdin protein

CAT: 0112-ATGP2745-500Size: 500 µgDry Ice: NoHazardous: No
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CAT#:0112-ATGP2745-500Size:500 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CFP is a plasma glycoprotein that positively regulates the alternative complement pathway of the innate immune system. This protein binds to many microbial surfaces and apoptotic cells and stabilizes the C3- and C5-convertase enzyme complexes in a feedback loop that ultimately leads to formation of the membrane attack complex and lysis of the target cell. Mutations in this gene result in two forms of properdin deficiency, which results in high susceptibility to meningococcal infections. Multiple alternatively spliced variants, encoding the same protein, have been identified. Recombinant human CFP protein, fused to His-tag at N-terminus, was expressed in E. coli.
Product Name Alternative
Complement factor properdin, BFD, PFC, PFD, PROPERDIN
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE, Denatured
Concentration
1 mg/mL (determined by Bradford assay)
Purity
> 80% by SDS-PAGE
Molecular Weight
50.9 kDa (465aa)
Additionnal Information
Properdin, Complement factor properdin, BFD, PFC, PFD, PROPERDIN, ATGP2745-10 µg, ATGP2745-20 µg, ATGP2745-50 µg, ATGP2745-100 µg, ATGP2745-250 µg, ATGP2745-500 µg, ATGP2745-1 mg, ATGP2745-10, ATGP2745-20, ATGP2745-50, ATGP2745-100, ATGP2745-250, ATGP2745-500, ATGP2745-1
References & Citations
Hartmann S., et al. (2000) J. Biol. Chem. 275:28569-28574; ; Liu T., et al. (2005) J. Proteome Res. 4:2070-2080;
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 0.4M urea, 10% glycerol
Scientific Category
Immunology
NCBI Accession Number
NP_002612
Uniprot Accession Number
P27918
Species
Human
AA Sequence
MGSSHHHHHH SSGLVPRGSH MGSDPVLCFT QYEESSGKCK GLLGGGVSVE DCCLNTAFAY QKRSGGLCQP CRSPRWSLWS TWAPCSVTCS EGSQLRYRRC VGWNGQCSGK VAPGTLEWQL QACEDQQCCP EMGGWSGWGP WEPCSVTCSK GTRTRRRACN HPAPKCGGHC PGQAQESEAC DTQQVCPTHG AWATWGPWTP CSASCHGGPH EPKETRSRKC SAPEPSQKPP GKPCPGLAYE QRRCTGLPPC PVAGGWGPWG PVSPCPVTCG LGQTMEQRTC NHPVPQHGGP FCAGDATRTH ICNTAVPCPV DGEWDSWGEW SPCIRRNMKS ISCQEIPGQQ SRGRTCRGRK FDGHRCAGQQ QDIRHCYSIQ HCPLKGSWSE WSTWGLCMPP CGPNPTRARQ RLCTPLLPKY PPTVSMVEGQ GEKNVTFWGR PLPRCEELQG QKLVVEEKRP CLHVPACKDP EEEEL

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