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Recombinant human IYD protein

CAT: 0112-ATGP2592-100Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0112-ATGP2592-100Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
IYD is an enzyme that catalyzes the oxidative NADPH-dependent deiodination of mono- and diiodotyrosine, which are the halogenated byproducts of thyroid hormone production. The N-terminus of the protein functions as a membrane anchor. Mutations in this gene cause congenital hypothyroidism due to dyshormonogenesis type 4, which is also referred to as deiodinase deficiency, or iodotyrosine dehalogenase deficiency, or thyroid hormonogenesis type 4. Alternative splicing results in multiple transcript variants. Recombinant human IYD protein, fused to His-tag at N-terminus, was expressed in E. coli.
Product Name Alternative
Iodotyrosine dehalogenase 1 isoform 3, C6orf71, DEHAL1, dJ422F24.1, TDH4
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
1 mg/mL (determined by Bradford assay)
Purity
> 90% by SDS-PAGE
Molecular Weight
25.1 kDa (214aa)
Additionnal Information
IYD, iodotyrosine dehalogenase 1 isoform 3, C6orf71, DEHAL1, dJ422F24.1, TDH4, ATGP2592-10 µg, ATGP2592-20 µg, ATGP2592-50 µg, ATGP2592-100 µg, ATGP2592-250 µg, ATGP2592-500 µg, ATGP2592-1 mg, ATGP2592-10, ATGP2592-20, ATGP2592-50, ATGP2592-100, ATGP2592-250, ATGP2592-500, ATGP2592-1
References & Citations
Burniat, A, et al. (2012) J. Clin. Endocrinol. Metab. 97 (7), E1276-E1283; ; Belevich, V.K., et al. (2011) Biomed Khim 57 (2), 187-194;
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 0.4M uREA, 10% glycerol
Scientific Category
Cardiovascular
NCBI Accession Number
NP_001158167
Uniprot Accession Number
Q6PHW0
Species
Human
AA Sequence
DRSMEKK KGEPRTRAEA RPWVDEDLKD SSDLHQAEED ADEWQESEEN VEHIPFSHNH YPEKEMVKRS QEFYELLNKR RSVRFISNEQ VPMEVIDNVI RTAGTAPSGA HTEPWTFVVV KDPDVKHKIR KIIEEEEEIN YMKRMGHRWV TDLKKLRTNW IKEYLDTAPI LILIFKQVHG FAANGKKKVH YYNE

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