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Recombinant human CCM2 protein

CAT: 0112-ATGP2496-010Size: 10 µgDry Ice: NoHazardous: No
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CAT#:0112-ATGP2496-010Size:10 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CCM2 provides instructions for making a protein called malcavernin, which strengthens the interactions between cells that form blood vessels and limits leakage from the vessels. It interacts with a number of other proteins to form a complex that is found in the junctions that connect neighboring cells. It helps turn off (suppress) a signaling molecule known as RhoA-GTPase. Recombinant human CCM2 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography.
Product Name Alternative
Malcavernin isoform 4, Malcavernin isoform 4, Malcavernin isoform 4
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
0.5 mg/mL (determined by Bradford assay)
Purity
> 90% by SDS-PAGE
Molecular Weight
34.3 kDa (311aa) confirmed by MALDI-TOF
Additionnal Information
CCM2, Malcavernin isoform 4, Malcavernin isoform 4, Malcavernin isoform 4, ATGP2496-10 µg, ATGP2496-20 µg, ATGP2496-50 µg, ATGP2496-100 µg, ATGP2496-250 µg, ATGP2496-500 µg, ATGP2496-1 mg, ATGP2496-10, ATGP2496-20, ATGP2496-50, ATGP2496-100, ATGP2496-250, ATGP2496-500, ATGP2496-1
References & Citations
Dupre N. et al. (2003) Can J Neurol Sci. 30:122-128; ; Liquori CL. et al. (2007) Am J Hum Genet. 80:69-75.;
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 20% glycerol, 1mM DTT
Scientific Category
Signal Transduction
NCBI Accession Number
NP_001161407
Uniprot Accession Number
Q9BSQ5
Species
Human
AA Sequence
EVKYLGQ LTSIPGYLNP SSRTEILHFI DNAKRAHQLP GHLTQEHDAV LSLSAYNVKL AWRDGEDIIL RVPIHDIAAV SYVRDDAAHL VVLKTDDSST KVDIKETYEV EASTFCFPES VDVGGASPHS KTISESELSA SATELLQDYM LTLRTKLSSQ EIQQFAALLH EYRNGASIHE FCINLRQLYG DSRKFLLLGL RPFIPEKDSQ HFENFLETIG VKDGRGIITD SFGRHRRALS TTSSSTTNGN RATGSSDDRS APSEGDEWDR MISDISSDIE ALGCSMDQDS A

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