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Recombinant human BEND6 protein

CAT: 0112-ATGP2441-500Size: 500 µgDry Ice: NoHazardous: No
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CAT#:0112-ATGP2441-500Size:500 µg
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Description
BEND6, as known as BEN domain-containing protein 6, is a neural BEN-solo factor that shares many functional attributes with Drosophila Insensitive, a co-repressor for the Drosophila CSL factor. This protein binds the mammalian CSL protein CBF1 and antagonizes Notch-dependent target activation. In addition, its association with Notch- and CBF1-regulated enhancers is promoted by CBF1 and antagonized by activated Notch. In utero electroporation experiments showed that ectopic BEND6 inhibited Notch-mediated self-renewal of neocortical neural stem cells and promoted neurogenesis. Recombinant human BEND6 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography.
Product Name Alternative
BEN domain-containing protein 6, bA203B9.1, C6orf65
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
1 mg/mL (determined by Bradford assay)
Purity
> 90% by SDS-PAGE
Molecular Weight
33.6 kDa (302aa) confirmed by MALDI-TOF
Additionnal Information
BEND6, BEN domain-containing protein 6, bA203B9.1, C6orf65, ATGP2441-10 µg, ATGP2441-20 µg, ATGP2441-50 µg, ATGP2441-100 µg, ATGP2441-250 µg, ATGP2441-500 µg, ATGP2441-1 mg, ATGP2441-10, ATGP2441-20, ATGP2441-50, ATGP2441-100, ATGP2441-250, ATGP2441-500, ATGP2441-1
References & Citations
Dai Q. et al. (2013) Development.. 140:1892-1902; ; Chu J. et al. (2004) J Biol Chem. 279:12337-12345.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol, 0.1M NaCl
Scientific Category
Other
NCBI Accession Number
NP_689944
Uniprot Accession Number
Q5SZJ8
Species
Human
AA Sequence
MQKIVQT DEITNTQAFR KGKRKRTETM DSENANSDMD KGQRDPYSGN AFLPGESSSE DEEPLAELSK EELCAKIKSL KEKLTNTRKE NSRLRQSLVM LQVLPQAVTQ FEELVGMAEA LLKGGGTMST SASTLWRATN NSSPDSFAST CSNSNSNSSS PVSLKPEEEH QTDEKQFQIE KWQIARCNKS KPQKFINDLM QVLYTNEYMA THSLTGAKSS TSRDKAVKPA MNQNEVQEII GVTKQLFPNT DDVSIRRMIG QKLNNCTKKP NLSKNLNSQD IK

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