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Recombinant human CUEDC2 protein

CAT: 0112-ATGP2299-500Size: 500 µgDry Ice: NoHazardous: No
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CAT#:0112-ATGP2299-500Size:500 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CUEDC2 belongs to the CUEDC2 family and contains 1 CUE domain. This protein down-regulates ESR1 protein levels through the ubiquitination-proteasome pathway, regardless of the presence of 17 beta-estradiol. It also involves in 17 beta-estradiol-induced ESR1 degradation and controls PGR protein levels through a similar mechanism. Recombinant human CUEDC2 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.
Product Name Alternative
CuE domain-containing protein 2, bA18I14.5, C10orf66
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
1 mg/mL (determined by Bradford assay)
Purity
> 90% by SDS-PAGE
Molecular Weight
34.4 kDa (310aa) confirmed by MALDI-TOF
Additionnal Information
CUEDC2, CuE domain-containing protein 2, bA18I14.5, C10orf66, ATGP2299-10 µg, ATGP2299-20 µg, ATGP2299-50 µg, ATGP2299-100 µg, ATGP2299-250 µg, ATGP2299-500 µg, ATGP2299-1 mg, ATGP2299-10, ATGP2299-20, ATGP2299-50, ATGP2299-100, ATGP2299-250, ATGP2299-500, ATGP2299-1
References & Citations
Pan X, Zhou T, et al. (2011) . Nat Med. 17 (6) :708-14. ; ; Zhang PJ, Zhao J, et al. (2007) . EMBO J. 26 (7) :1831-42.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 0.15M NaCl, 20% glycerol, 1mM DTT
Scientific Category
Signal Transduction
NCBI Accession Number
NP_076945
Uniprot Accession Number
Q9H467
Species
Human
AA Sequence
MELERIV SAALLAFVQT HLPEADLSGL DEVIFSYVLG VLEDLGPSGP SEENFDMEAF TEMMEAYVPG FAHIPRGTIG DMMQKLSGQL SDARNKENLQ PQSSGVQGQV PISPEPLQRP EMLKEETRSS AAAAADTQDE ATGAEEELLP GVDVLLEVFP TCSVEQAQWV LAKARGDLEE AVQMLVEGKE EGPAAWEGPN QDLPRRLRGP QKDELKSFIL QKYMMVDSAE DQKIHRPMAP KEAPKKLIRY IDNQVVSTKG ERFKDVRNPE AEEMKATYIN LKPARKYRFH

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