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Recombinant human BSND protein

CAT: 0112-ATGP2204-050Size: 50 µgDry Ice: NoHazardous: No
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CAT#:0112-ATGP2204-050Size:50 µg
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Description
BSND is an essential beta subunit for CLC chloride channels. These heteromeric channels localize to basolateral membranes of renal tubules and of potassium-secreting epithelia of the inner ear. Mutations in this BSND have been associated with Bartter syndrome with sensorineural deafness. Recombinant human BSND protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.
Product Name Alternative
Barttin, BART, DFNB73
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
0.25 mg/mL (determined by Bradford assay)
Purity
> 90% by SDS-PAGE
Molecular Weight
31.7 kDa (290aa) confirmed by MALDI-TOF
Additionnal Information
BSND, Barttin, BART, DFNB73, ATGP2204-10 µg, ATGP2204-20 µg, ATGP2204-50 µg, ATGP2204-100 µg, ATGP2204-250 µg, ATGP2204-500 µg, ATGP2204-1 mg, ATGP2204-10, ATGP2204-20, ATGP2204-50, ATGP2204-100, ATGP2204-250, ATGP2204-500, ATGP2204-1
References & Citations
Park, C.W., et al. (2011) Clin. Nephrol. 75 (SuPPL 1), 69-74; ; Iqbal, H., et al. (2011) J. Biomed. Biotechnol. 2011, 304612;
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 0.15M NaCl, 10% glycerol, 1mM DTT
Scientific Category
Metabolism
NCBI Accession Number
NP_476517
Uniprot Accession Number
Q8WZ55
Species
Human
AA Sequence
CQCYPKI TFVPADSDFQ GILSPKAMGL LENGLAAEMK SPSPQPPYVR LWEEAAYDQS LPDFSHIQMK VMSYSEDHRS LLAPEMGQPK LGTSDGGEGG PGDVQAWMEA AVVIHKGSDE SEGERRLTQS WPGPLACPQG PAPLASFQDD LDMDSSEGSS PNASPHDREE ACSPQQEPQG CRCPLDRFQD FALIDAPTLE DEPQEGQQWE IALPNNWQRY PRTKVEEKEA SDTGGEEPEK EEEDLYYGLP DGAGDLLPDK ELGFEPDTQG

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