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Recombinant human CD46 protein

CAT: 0112-ATGP2036-500Size: 500 µgDry Ice: NoHazardous: No
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CAT#:0112-ATGP2036-500Size:500 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Membrane cofactor protein isoform 14, also known as CD46, is a type I membrane protein that has cofactor activity for inactivation of complement components C3b and C4b by serum factor I. This function resides in the complement control protein repeats (CCPs), with CCP1-4 essential for regulation. CD46 is widely distributed on thymocytes, T cells, B cells, monocytes, granulocytes, NK cells, platelets, endothelial cells, epithelial cells, fibroblasts, placenta and sperm, but not on erythrocyte. Recombinant human CD46 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.
Product Name Alternative
Membrane cofactor protein isoform 14, AHuS2, MCP, MIC10, TLX, TRA2.10
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
0.5 mg/mL (determined by Bradford assay)
Purity
> 85% by SDS-PAGE
Molecular Weight
33.8 kDa (302aa) confirmed by MALDI-TOF
Additionnal Information
CD46, Membrane cofactor protein isoform 14, AHuS2, MCP, MIC10, TLX, TRA2.10, ATGP2036-10 µg, ATGP2036-20 µg, ATGP2036-50 µg, ATGP2036-100 µg, ATGP2036-250 µg, ATGP2036-500 µg, ATGP2036-1 mg, ATGP2036-10, ATGP2036-20, ATGP2036-50, ATGP2036-100, ATGP2036-250, ATGP2036-500, ATGP2036-1
References & Citations
Riley R C., et al. (2002) Mol Reprod Dev. 62:534-546.; ; Iwata K., et al. (1995) J Biol Chem. 270:15148-15152.;
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 0.1M NaCl, 20% glycerol
Scientific Category
Immunology
NCBI Accession Number
NP_758860.1
Uniprot Accession Number
P15529
Species
Human
AA Sequence
CEEPPTF EAMELIGKPK PYYEIGERVD YKCKKGYFYI PPLATHTICD RNHTWLPVSD DACYRETCPY IRDPLNGQAV PANGTYEFGY QMHFICNEGY YLIGEEILYC ELKGSVAIWS GKPPICEKVL CTPPPKIKNG KHTFSEVEVF EYLDAVTYSC DPAPGPDPFS LIGESTIYCG DNSVWSRAAP ECKVVKCRFP VVENGKQISG FGKKFYYKAT VMFECDKGFY LDGSDTIVCD SNSTWDPPVP KCLKGPRPTY KPPVSNYPGY PKPEEGILDS LD

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