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Recombinant human TDP2 protein

CAT: 0112-ATGP2024-010Size: 10 µgDry Ice: NoHazardous: No
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CAT#:0112-ATGP2024-010Size:10 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
TDP2 is a member of a superfamily of divalent cation-dependent phosphodiesterases. The protein associates with CD40, tumor necrosis factor (TNF) receptor-75 and TNF receptor associated factors (TRAFs), and inhibits nuclear factor-kappa-B activation. This protein has sequence and structural similarities with APE1 endonuclease, which is involved in both DNA repair and the activation of transcription factors. Recombinant human TDP2 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.
Product Name Alternative
Tyrosyl-DNA phosphodiesterase 2, AD022, dJ30M3.3, EAP2, EAPII, RP1-30M3.3, TTRAP
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
0.5 mg/mL (determined by Bradford assay)
Purity
> 85% by SDS-PAGE
Molecular Weight
43.3 kDa (385aa) confirmed by MALDI-TOF
Additionnal Information
TDP2, Tyrosyl-DNA phosphodiesterase 2, AD022, dJ30M3.3, EAP2, EAPII, RP1-30M3.3, TTRAP, ATGP2024-10 µg, ATGP2024-20 µg, ATGP2024-50 µg, ATGP2024-100 µg, ATGP2024-250 µg, ATGP2024-500 µg, ATGP2024-1 mg, ATGP2024-10, ATGP2024-20, ATGP2024-50, ATGP2024-100, ATGP2024-250, ATGP2024-500, ATGP2024-1
References & Citations
Vilotti, S., et al. (2012) Cell Death Differ. 19 (3), 488-500; ; Pinel, P., et al. (2012) J. Neurosci. 32 (3), 817-825;
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 0.15M NaCl, 10% glycerol, 1mM DTT
Scientific Category
Cancer
NCBI Accession Number
NP_057698
Uniprot Accession Number
O95551
Species
Human
AA Sequence
MELGSCL EGGREAAEEE GEPEVKKRRL LCVEFASVAS CDAAVAQCFL AENDWEMERA LNSYFEPPVE ESALERRPET ISEPKTYVDL TNEETTDSTT SKISPSEDTQ QENGSMFSLI TWNIDGLDLN NLSERARGVC SYLALYSPDV IFLQEVIPPY YSYLKKRSSN YEIITGHEEG YFTAIMLKKS RVKLKSQEII PFPSTKMMRN LLCVHVNVSG NELCLMTSHL ESTRGHAAER MNQLKMVLKK MQEAPESATV IFAGDTNLRD REVTRCGGLP NNIVDVWEFL GKPKHCQYTW DTQMNSNLGI TAACKLRFDR IFFRAAAEEG HIIPRSLDLL GLEKLDCGRF PSDHWGLLCN LDIIL

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