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Recombinant human AICDA protein

CAT: 0112-ATGP1895-500Size: 500 µgDry Ice: NoHazardous: No
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CAT#:0112-ATGP1895-500Size:500 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
AICDA, also known as AID, is involved in somatic hypermutation, gene conversion, and class-switch recombination in B-lymphocytes. This protein is required for several crucial steps of B-cell terminal differentiation necessary for efficient antibody responses. It may also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation. Recombinant human AICDA protein, fused to His-tag at N-terminus, was expressed in E. coli.
Product Name Alternative
Activation-induced cytidine deaminase, AID, ARP2, CDA2, HIGM2
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE, Denatured
Concentration
0.5 mg/mL (determined by Bradford assay)
Purity
> 85% by SDS-PAGE
Molecular Weight
26.1 kDa (218aa)
Additionnal Information
AICDA, Activation-induced cytidine deaminase, AID, ARP2, CDA2, HIGM2, ATGP1895-10 µg, ATGP1895-20 µg, ATGP1895-50 µg, ATGP1895-100 µg, ATGP1895-250 µg, ATGP1895-500 µg, ATGP1895-1 mg, ATGP1895-10, ATGP1895-20, ATGP1895-50, ATGP1895-100, ATGP1895-250, ATGP1895-500, ATGP1895-1
References & Citations
Guo J.u., et al. (2010) Cell. 145:423-434; ; Noguchi E., et al. (2001) J. Allergy Clin. 108:382-386
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 0.4M urea, 10% glycerol
Scientific Category
Epigenomics (Transcription & Translation)
NCBI Accession Number
NP_065712.1
Uniprot Accession Number
Q9GZX7
Species
Human
AA Sequence
MDSLLMNRRK FLYQFKNVRW AKGRRETYLC YVVKRRDSAT SFSLDFGYLR NKNGCHVELL FLRYISDWDL DPGRCYRVTW FTSWSPCYDC ARHVADFLRG NPNLSLRIFT ARLYFCEDRK AEPEGLRRLH RAGVQIAIMT FKDYFYCWNT FVENHERTFK AWEGLHENSV RLSRQLRRIL LPLYEVDDLR DAFRTLGL

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