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Recombinant human ASGR2 protein

CAT: 0112-ATGP1776-500Size: 500 µgDry Ice: NoHazardous: No
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CAT#:0112-ATGP1776-500Size:500 µg
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Description
ASGR2 is a subunit of the asialoglycoprotein receptor. This receptor is a transmembrane protein that plays a critical role in serum glycoprotein homeostasis by mediating the endocytosis and lysosomal degradation of glycoproteins with exposed terminal galactose or N-acetylgalactosamine residues. It may facilitate hepatic infection by multiple viruses including hepatitis B, and is also a target for liver-specific drug delivery. ASGR2 is a hetero-oligomeric protein composed of major and minor subunits, which are encoded by different genes. ASGR2 is the less abundant minor subunit. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. Recombinant human ASGR2 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.
Product Name Alternative
Asialoglycoprotein receptor 2, ASGP-R2; ASGPR2; CLEC4H2; HBXBP; HL-2
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
0.5 mg/mL (determined by Bradford assay)
Purity
> 90% by SDS-PAGE
Molecular Weight
28.9 kDa (255aa) confirmed by MALDI-TOF
Additionnal Information
ASGR2, Asialoglycoprotein receptor 2, ASGP-R2; ASGPR2; CLEC4H2; HBXBP; HL-2, ATGP1776-10 µg, ATGP1776-20 µg, ATGP1776-50 µg, ATGP1776-100 µg, ATGP1776-250 µg, ATGP1776-500 µg, ATGP1776-1 mg, ATGP1776-10, ATGP1776-20, ATGP1776-50, ATGP1776-100, ATGP1776-250, ATGP1776-500, ATGP1776-1
References & Citations
Seow YY., et al. (2002) . Nephron. 91 (3) :431-8.; ; Veselkin E., et al. (2011) . PLoS One. 6 (11) :e27210.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 0.2M NaCl, 30% glycerol, 1mM DTT
Scientific Category
Signal Transduction
NCBI Accession Number
NP_001172
Uniprot Accession Number
P07307
Species
Human
AA Sequence
MGSSHHHHHH SSGLVPRGSH MGSQSEGHRG AQLQAELRSL KEAFSNFSSS TLTEVQAIST HGGSVGDKIT SLGAKLEKQQ QDLKADHDAL LFHLKHFPVD LRFVACQMEL LHSNGSQRTC CPVNWVEHQG SCYWFSHSGK AWAEAEKYCQ LENAHLVVIN SWEEQKFIVQ HTNPFNTWIG LTDSDGSWKW VDGTDYRHNY KNWAVTQPDN WHGHELGGSE DCVEVQPDGR WNDDFCLQVY RWVCEKRRNA TGEVA

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