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Recombinant human C4BPB protein

CAT: 0112-ATGP1664-020Size: 20 µgDry Ice: NoHazardous: No
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CAT#:0112-ATGP1664-020Size:20 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
C4BPB is a member of a superfamily of proteins composed predominantly of tandemly arrayed short consensus repeats of approximately 60 amino acids. A single, unique beta-chain of this protein assembles with seven identical alpha-chains into the predominant isoform of C4b-binding protein, a multimeric protein that controls activation of the complement cascade through the classical pathway. C4b-binding protein has a regulatory role in the coagulation system also, mediated through the beta-chain binding of protein S, a vitamin K-dependent protein that serves as a cofactor of activated protein C. Recombinant human C4BPB protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.
Product Name Alternative
Complement component 4 binding protein beta, C4BP, C4b-binding protein beta chain
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
1 mg/mL (determined by Bradford assay)
Purity
> 90% by SDS-PAGE
Molecular Weight
29kDa (260aa) confirmed by MALDI-TOF
Additionnal Information
C4BPB, ATGP1664-10 µg, ATGP1664-20 µg, ATGP1664-50 µg, ATGP1664-100 µg, ATGP1664-250 µg, ATGP1664-500 µg, ATGP1664-1 mg, ATGP1664-10, ATGP1664-20, ATGP1664-50, ATGP1664-100, ATGP1664-250, ATGP1664-500, ATGP1664-1
References & Citations
Carlsson, S.et al. (2010) J. Biol. Chem. 285 (42), 32038-32046; ; Buil, A., et al. (2010) Blood 115 (23), 4644-4650
Other References
Sugimoto M, et al. Increased expression of Protein S in eyes with diabetic retinopathy and diabetic macular edema. (Sci Rep. 2021) {https://pubmed.ncbi.nlm.nih.gov/34001977/}; ; Urawa M, et al. Protein S is protective in pulmonary fibrosis. (J Thromb Haemost. 2016) {https://pubmed.ncbi.nlm.nih.gov/27172994/}; ; Yasuma T, et al. Amelioration of Diabetes by Protein S. (Diabetes. 2016) {https://pubmed.ncbi.nlm.nih.gov/27207541/}
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol, 0.15M NaCl
Scientific Category
Immunology
NCBI Accession Number
NP_000707
Uniprot Accession Number
P20851
Species
Human
AA Sequence
SDAEH CPELPPVDNS IFVAKEVEGQ ILGTYVCIKG YHLVGKKTLF CNASKEWDNT TTECRLGHCP DPVLVNGEFS SSGPVNVSDK ITFMCNDHYI LKGSNRSQCL EDHTWAPPFP ICKSRDCDPP GNPVHGYFEG NNFTLGSTIS YYCEDRYYLV GVQEQQCVDG EWSSALPVCK LIQEAPKPEC EKALLAFQES KNLCEAMENF MQQLKESGMT MEELKYSLEL KKAELKAKLL

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