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Recombinant human SRR protein

CAT: 0112-ATGP1369-050Size: 50 µgDry Ice: NoHazardous: No
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CAT#:0112-ATGP1369-050Size:50 µg
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Description
SRR, also known as serine racemase, is an enzyme which generates D-serine from L-serine. D-serine acts as a neuronal signaling molecule by activating NMDA receptors in the brain. Mammalian serine racemase is a pyridoxal 5'-phosphate dependent enzyme that catalyzes both the racemization of L-serine to D-serine and also the elimination of water from L-serine, generating pyruvate and ammonia. The enzyme is physiologically stimulated by divalent cations (e. g., magnesium) and is allosterically activated by the magnesium/ATP complex. Recombinant human SRR protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography.
Product Name Alternative
Serine racemase, ILV1, ISO1
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
0.5 mg/mL (determined by Bradford assay)
Purity
> 85% by SDS-PAGE
Molecular Weight
39.1 kDa (364aa) confirmed by MALDI-TOF
Additionnal Information
SRR, Serine racemase, ILV1, ISO1, ATGP1369-10 µg, ATGP1369-20 µg, ATGP1369-50 µg, ATGP1369-100 µg, ATGP1369-250 µg, ATGP1369-500 µg, ATGP1369-1 mg, ATGP1369-10, ATGP1369-20, ATGP1369-50, ATGP1369-100, ATGP1369-250, ATGP1369-500, ATGP1369-1
References & Citations
De Miranda J., et al. (2000) Gene. 256:183-188; ; Smith M.A., et al. (2010) J. Biol. Chem. 285:12873-12881
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 20% glycerol, 0.1M NaCl, 1mM DTT
Scientific Category
Neuroscience
NCBI Accession Number
NP_068766
Uniprot Accession Number
Q9GZT4
Species
Human
AA Sequence
MGSSHHHHHH SSGLVPRGSH MGSHMCAQYC ISFADVEKAH INIRDSIHLT PVLTSSILNQ LTGRNLFFKC ELFQKTGSFK IRGALNAVRS LVPDALERKP KAVVTHSSGN HGQALTYAAK LEGIPAYIVV PQTAPDCKKL AIQAYGASIV YCEPSDESRE NVAKRVTEET EGIMVHPNQE PAVIAGQGTI ALEVLNQVPL VDALVVPVGG GGMLAGIAIT VKALKPSVKV YAAEPSNADD CYQSKLKGKL MPNLYPPETI ADGVKSSIGL NTWPIIRDLV DDIFTVTEDE IKCATQLVWE RMKLLIEPTA GVGVAAVLSQ HFQTVSPEVK NICIVLSGGN VDLTSSITWV KQAERPASYQ SVSV

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