Recombinant human DNA polymerase lambda/POLL protein

CAT: 0112-ATGP1255-020Size: 20 µgDry Ice: NoHazardous: No
CAT#:0112-ATGP1255-020Size:20 µg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
DNA polymerase lambda, also known as POLL, is a DNA polymerase involved in base excision repair (BER) . POLL is a low-fidelity polymerase which plays a role in both spontaneous and DNA damage-induced mutagenesis. In addition, POLL may play a role in the mutagenic bypass of T-T dimers. Pol lambda possesses terminal transferase and 5'-deoxyribose-5-phosphate lyase activity. These activities have been found to be coordinated by PCNA and replication protein A. Recombinant human POLL protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.
Product Name Alternative
DNA polymerase lambda, BETA-N, POL-KAPPA, Pol beta2, POLKAPPA
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
0.5 mg/mL (determined by Bradford assay)
Purity
> 90% by SDS-PAGE
Molecular Weight
36 kDa (320aa) confirmed by MALDI-TOF
Additionnal Information
POLL, ATGP1255-10 µg, ATGP1255-20 µg, ATGP1255-50 µg, ATGP1255-100 µg, ATGP1255-250 µg, ATGP1255-500 µg, ATGP1255-1 mg, ATGP1255-10, ATGP1255-20, ATGP1255-50, ATGP1255-100, ATGP1255-250, ATGP1255-500, ATGP1255-1
References & Citations
O Wang J., et al. (2001) Cancer Res. 61:5366-5369.; ; Zhang Y., et al. (2000) Nucleic Acids Res. 28:4147-4156.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 1mM DTT, 30% glycerol, 0.1M NaCl
Scientific Category
Epigenetics and Nuclear Signaling
NCBI Accession Number
AAH03548
Uniprot Accession Number
Q9UGP5
Species
Human
AA Sequence
MLMHHQKYLQ RFLGGKREKK QKEACSIPGI GKRMAEKIIE ILESGHLRKL DHISESVPVL ELFSNIWGAG TKTAQMWYQQ GFRSLEDIRS QASLTTQQAI GLKHYSDFLE RMPREEATEI EQTVQKAAQA FNSGLLCVAC GSYRRGKATC GDVDVLITHP DGRSHRGIFS RLLDSLRQEG FLTDDLVSQE ENGQQQKYLG VCRLPGPGRR HRRLDIIVVP YSEFACALLY FTGSAHFNRS MRALAKTKGM SLSEHALSTA VVRNTHGCKV GPGRVLPTPT EKDVFRLLGL PYREPAERDW

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