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Recombinant human RAB32 protein

CAT: 0112-ATGP1246-500Size: 500 µgDry Ice: NoHazardous: No
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CAT#:0112-ATGP1246-500Size:500 µg
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Description
RAB32 belongs to the small GTPase superfamily. RAB32 modulates ER calcium handling and disrupts the specific enrichment of calnexin on the MAM (mitochondria-associated membrane), while not affecting the ER distribution of protein-disulfide isomerase and mitofusin-2. Also, RAB32 determines the targeting of PKA (cAMP-dependent protein kinase) to mitochondrial and ER membranes and through its overexpression or inactivation increases the phosphorylation of Bad and of Drp1. Through a combination of its functions as a PKA-anchoring protein and a regulator of MAM properties, the activity and expression level of RAB32 determine the speed of apoptosis onset. Recombinant human RAB32 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.
Product Name Alternative
Ras-related protein Rab-32, RAB32 member RAS oncogene family
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
0.5 mg/mL (determined by Bradford assay)
Purity
> 90% by SDS-PAGE
Molecular Weight
27.5 kDa (249aa) confirmed by MALDI-TOF
Additionnal Information
RAB32, Ras-related protein Rab-32, ATGP1246-10 µg, ATGP1246-20 µg, ATGP1246-50 µg, ATGP1246-100 µg, ATGP1246-250 µg, ATGP1246-500 µg, ATGP1246-1 mg, ATGP1246-10, ATGP1246-20, ATGP1246-50, ATGP1246-100, ATGP1246-250, ATGP1246-500, ATGP1246-1
References & Citations
Bui M, et al. (2010) J Biol Chem. 285 (41) :31590-602.; ; Alto NM, et al. (2002) J Cell Biol.158 (4) :659-68.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 5mM DTT, 50% glycerol, 200 mM NaCl, 2mM EDTA
Scientific Category
Signal Transduction
NCBI Accession Number
NP_006825
Uniprot Accession Number
Q13637
Species
Human
AA Sequence
MAGGGA GDPGLGAAAA PAPETREHLF KVLVIGELGV GKTSIIKRYV HQLFSQHYRA TIGVDFALKV LNWDSRTLVR LQLWDIAGQE RFGNMTRVYY KEAVGAFVVF DISRSSTFEA VLKWKSDLDS KVHLPNGSPI PAVLLANKCD QNKDSSQSPS QVDQFCKEHG FAGWFETSAK DNINIEEAAR FLVEKILVNH QSFPNEENDV DKIKLDQETL RAENKSQCC

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