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Recombinant human TPM4 protein

CAT: 0112-ATGP0992-100Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0112-ATGP0992-100Size:100 µg
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Description
TPM4 belongs to the tropomyosin family. Tropomyosins are present in virtually all eukaryotic cells (both muscle and nonmuscle), where they bind actin filaments and function to modulate actin-myosin interaction and stabilize actin filament structure. TPM4 binds to actin filaments in muscle and nonmuscle cells and plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. Recombinant human TPM4 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.
Product Name Alternative
Tropomyosin alpha-4 chain, Tropomyosin 4
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
1 mg/mL (determined by Bradford assay)
Purity
> 85% by SDS-PAGE
Molecular Weight
30.7 kDa (268aa) confirmed by MALDI-TOF
Additionnal Information
TPM4, Tropomyosin alpha-4 chain, Tropomyosin 4, ATGP0992-10 µg, ATGP0992-20 µg, ATGP0992-50 µg, ATGP0992-100 µg, ATGP0992-250 µg, ATGP0992-500 µg, ATGP0992-1 mg, ATGP0992-10, ATGP0992-20, ATGP0992-50, ATGP0992-100, ATGP0992-250, ATGP0992-500, ATGP0992-1
References & Citations
Lehman W., et al. (2000) J Mol Biol. 302 (3) :593-606. ; ; Wilton SD., et al. (1996) Cytogenet Cell Genet. 72 (4) :294-6.
Other References
Karasawa R, et al. Association of Anti-TPM4 autoantibodies with vasculopathic cutaneous manifestations in juvenile dermatomyositis. (Rheumatology (Oxford) . 2023) {https://pubmed.ncbi.nlm.nih.gov/37144941/}
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol, 2mM DTT, 0.1M NaCl.
Scientific Category
Cytoskeleton
NCBI Accession Number
NP_003281
Uniprot Accession Number
P67936
Species
Human
AA Sequence
MGSSHHHHHH SSGLVPRGSH MAGLNSLEAV KRKIQALQQQ ADEAEDRAQG LQRELDGERE RREKAEGDVA ALNRRIQLVE EELDRAQERL ATALQKLEEA EKAADESERG MKVIENRAMK DEEKMEIQEM QLKEAKHIAE EADRKYEEVA RKLVILEGEL ERAEERAEVS ELKCGDLEEE LKNVTNNLKS LEAASEKYSE KEDKYEEEIK LLSDKLKEAE TRAEFAERTV AKLEKTIDDL EEKLAQAKEE NVGLHQTLDQ TLNELNCI

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