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Recombinant human TDO2 protein

CAT: 0112-ATGP0939-050Size: 50 µgDry Ice: NoHazardous: No
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CAT#:0112-ATGP0939-050Size:50 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
TDO2, also known as TDO, is a ferrous heme enzyme that catalyzes the first and rate-limiting step in the kynurenine pathway, the major pathway of tryptophan metabolism. It incorporates oxygen into the indole moiety of tryptophan. It has a broad specificity towards tryptamine and derivatives including D- and L-tryptophan, 5-hydroxytryptophan and serotonin. Recombinant human TDO2 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.
Product Name Alternative
Tryptophan 23-dioxygenase, Tryptophan 2,3-dioxygenase, TDO, TPH2, TRPO
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
0.25 mg/mL (determined by Bradford assay)
Purity
> 90% by SDS-PAGE
Molecular Weight
50 kDa (426aa) confirmed by MALDI-TOF
Additionnal Information
TDO2, Tryptophan 23-dioxygenase, Tryptophan 2,3-dioxygenase, TDO, TPH2, TRPO, ATGP0939-10 µg, ATGP0939-20 µg, ATGP0939-50 µg, ATGP0939-100 µg, ATGP0939-250 µg, ATGP0939-500 µg, ATGP0939-1 mg, ATGP0939-10, ATGP0939-20, ATGP0939-50, ATGP0939-100, ATGP0939-250, ATGP0939-500, ATGP0939-1
References & Citations
Murray MF., et al. (2007) Curr Drug Metab. 8 (3) :197-200.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 0.2M NaCl, 5mM DTT, 1mM EDTA, 30% glycerol
Scientific Category
Metabolism
NCBI Accession Number
NP_005642
Uniprot Accession Number
P48775
Species
Human
AA Sequence
MSGCPFLGNN FGYTFKKLPV EGSEEDKSQT GVNRASKGGL IYGNYLHLEK VLNAQELQSE TKGNKIHDEH LFIITHQAYE LWFKQILWEL DSVREIFQNG HVRDERNMLK VVSRMHRVSV ILKLLVQQFS ILETMTALDF NDFREYLSPA SGFQSLQFRL LENKIGVLQN MRVPYNRRHY RDNFKGEENE LLLKSEQEKT LLELVEAWLE RTPGLEPHGF NFWGKLEKNI TRGLEEEFIR IQAKEESEEK EEQVAEFQKQ KEVLLSLFDE KRHEHLLSKG ERRLSYRALQ GALMIYFYRE EPRFQVPFQL LTSLMDIDSL MTKWRYNHVC MVHRMLGSKA GTGGSSGYHY LRSTVSDRYK VFVDLFNLST YLIPRHWIPK MNPTIHKFLY TAEYCDSSYF SSDESD

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