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Recombinant human CCS protein

CAT: 0112-ATGP0715-100Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0112-ATGP0715-100Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CCS is essential for the incorporation of copper into SOD-1, and therefore is necessary for its enzymatic activity. CCS prevents copper ions from binding to intracellular copper scavengers and provides the SOD-1 enzyme with the necessary copper cofactor. CCS escorts copper only to SOD-1 and fails to deliver copper to proteins in the mitochondria, nucleus or secretory pathway. While many tissues express CCS, the chaperone is most abundant in the kidney, liver and Purkinje cells in the neuropil of the central nervous system. Recombinant human CCS protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.
Product Name Alternative
Copper chaperone for superoxide dismutase
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
1 mg/mL (determined by Bradford assay)
Purity
> 90% by SDS-PAGE
Molecular Weight
31.2 kDa (294aa) confirmed by MALDI-TOF
Additionnal Information
CCS, Copper chaperone for superoxide dismutase, ATGP0715-10 µg, ATGP0715-20 µg, ATGP0715-50 µg, ATGP0715-100 µg, ATGP0715-250 µg, ATGP0715-500 µg, ATGP0715-1 mg, ATGP0715-10, ATGP0715-20, ATGP0715-50, ATGP0715-100, ATGP0715-250, ATGP0715-500, ATGP0715-1
References & Citations
Romerius P., et al. (2010) Clin Cancer Res. 16 (15) :3843-50.; ; Seetharaman SV., et al. (2010) Biochemistry. 49 (27) :5714-25.;
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 0.2M NaCl 1mM DTT, 10% glycerol
Scientific Category
Cancer
NCBI Accession Number
NP_005116
Uniprot Accession Number
O14618
Species
Human
AA Sequence
MASDSGNQGT LCTLEFAVQM TCQSCVDAVR KSLQGVAGVQ DVEVHLEDQM VLVHTTLPSQ EVQALLEGTG RQAVLKGMGS GQLQNLGAAV AILGGPGTVQ GVVRFLQLTP ERCLIEGTID GLEPGLHGLH VHQYGDLTNN CNSCGNHFNP DGASHGGPQD SDRHRGDLGN VRADADGRAI FRMEDEQLKV WDVIGRSLII DEGEDDLGRG GHPLSKITGN SGERLACGII ARSAGLFQNP KQICSCDGLT IWEERGRPIA GKGRKESAQP PAHL

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