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Recombinant human CACYBP protein

CAT: 0112-ATGP0566-100Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0112-ATGP0566-100Size:100 µg
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Description
CACYBP is primarily a nuclear protein that contains one CS domain and one SGS domain. It is believed to be involved in calcium-dependent ubiquitination and subsequent proteosomal degradation of target proteins. It most likely serves as a molecular bridge in ubiquitin E3 complexes. It also participates in the ubiquitin-mediated degradation of beta-catenin. CACYBP is thought to be a potential inhibitor of cell growth and invasion in the gastric cancer cell through its effects on beta-catenin protein expression and transcriptional activation of TCF/LEF. Recombinant human CACYBP protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.
Product Name Alternative
Clcyclin-binding protein, GIG5, PNAS-107, RP1-102G20.6, S100A6BP, SIP, Clcyclin-binding protein CACYBP, Calcyclin binding protein, GIG 5, Growth inhibiting gene 5, Growth inhibiting gene 5 protein, hCacyBP, MGC87971, PNAS 107, PNAS107, RP1 102G20.6, S100A6 binding protein.
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
1 mg/mL (determined by Bradford assay)
Purity
> 85% by SDS-PAGE
Molecular Weight
23.4 kDa (205aa) confirmed by MALDI-TOF
Additionnal Information
CACYBP, Clcyclin-binding protein, GIG5, PNAS-107, RP1-102G20.6, S100A6BP, SIP, Clcyclin-binding protein CACYBP, Calcyclin binding protein, GIG 5, Growth inhibiting gene 5, Growth inhibiting gene 5 protein, hCacyBP, MGC87971, PNAS 107, PNAS107, RP1 102G20.6, S100A6 binding protein., ATGP0566-10 µg, ATGP0566-20 µg, ATGP0566-50 µg, ATGP0566-100 µg, ATGP0566-250 µg, ATGP0566-500 µg, ATGP0566-1 mg, ATGP0566-10, ATGP0566-20, ATGP0566-50, ATGP0566-100, ATGP0566-250, ATGP0566-500, ATGP0566-1
References & Citations
Matsuzawa SI., et al. (2001) Mol Cell. 7 (5) :915-26. ; ; Filipek A., et al. (2002) J Biol Chem. 277 (23) :21103-9.;
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol, 1mM DTT, 0.1M NaCl.
Scientific Category
Ubiquitination
NCBI Accession Number
NP_001007215
Uniprot Accession Number
Q9HB71
Species
Human
AA Sequence
MQQKSQKKAE LLDNEKPAAV VAPITTGYTV KISNYGWDQS DKFVKIYITL TGVHQVPTEN VQVHFTERSF DLLVKNLNGK SYSMIVNNLL KPISVEGSSK KVKTDTVLIL CRKKVENTRW DYLTQVEKEC KEKEKPSYDT ETDPSEGLMN VLKKIYEDGD DDMKRTINKA WVESREKQAK GDTEF

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