IHMT-PI3Kδ-372

IHMT-PI3Kδ-372

• CAS Number: 2429889-61-0
• UNSPSC Description: IHMT-PI3Kδ-372 is a potent and selective PI3Kδ inhibitor with an IC50 of 14 nM. IHMT-PI3Kδ-372 shows high selectivity over other class I PI3Ks (56～83 fold) and other protein kinases. IHMT-PI3Kδ-372 can be uesd for chronic obstructive pulmonary disease (COPD) research[1].
• Target Antigen: Cytochrome P450; PI3K
• Type: Reference compound
• Related Pathways: Metabolic Enzyme/Protease;PI3K/Akt/mTOR
• Field of Research: Inflammation/Immunology
• Assay Protocol: https://www.medchemexpress.com/ihmt-pi3kδ-372.html
• Solubility: DMSO : 41.67 mg/mL (ultrasonic)
• Smiles: O=C1N(C2CC2)C([C@@H](N3N=C(C4=CC=C(OC)C(F)=C4)C5=C(N)N=CN=C53)CC)=NC6=C1C(F)=CC=C6
• Molecular Weight: 503.50
• References & Citations: [1]Feng Li, et al. Discovery of (S)-2-(1-(4-Amino-3-(3-fluoro-4-methoxyphenyl)-1 H-pyrazolo[3,4- d]pyrimidin-1-yl)propyl)-3-cyclopropyl-5-fluoroquinazolin-4(3 H)-one (IHMT-PI3Kδ-372) as a Potent and Selective PI3Kδ Inhibitor for the Treatment of Chronic Obstructive Pulmonary Disease. J Med Chem. 2020 Nov 25;63(22):13973-13993.
• Shipping Conditions: Room Temperature
• Storage Conditions: -20°C, 3 years; 4°C, 2 years (Powder)
• Clinical Information: No Development Reported