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Recombinant human MAT1A protein

CAT: 0112-ATGP0489-010Size: 10 µgDry Ice: NoHazardous: No
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CAT#:0112-ATGP0489-010Size:10 µg
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Description
MAT1A catalyzes the formation of S-adenosyltransferase (AdoMet) for methionine catabolism in the liver. MAT1A expression also correlates with a differentiated phenotype, whereas liver cells expressing MAT2A present a dedifferentiated phenotype and lowered AdoMet synthesis. Likewise, NFkappaB and TNFalpha cause a switch from MAT1A to MAT2A expression in human hepatocellular carcinoma (HCC), which facilitates cancer cell growth. Recombinant human MAT1A protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.
Product Name Alternative
S-adenosylmethionine synthetase, MAT, MATA1, SAMS, SAMS1, methionine adenosyltransferase I alpha, S-adenosylmethionine synthetase, MAT1A
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
0.5 mg/mL (determined by Bradford assay)
Purity
> 95% by SDS-PAGE
Molecular Weight
45.8 kDa (415aa) confirmed by MALDI-TOF
Additionnal Information
MAT1A, S-adenosylmethionine synthetase, MAT, MATA1, SAMS, SAMS1, methionine adenosyltransferase I alpha, S-adenosylmethionine synthetase, MAT1A, ATGP0489-10 µg, ATGP0489-20 µg, ATGP0489-50 µg, ATGP0489-100 µg, ATGP0489-250 µg, ATGP0489-500 µg, ATGP0489-1 mg, ATGP0489-10, ATGP0489-20, ATGP0489-50, ATGP0489-100, ATGP0489-250, ATGP0489-500, ATGP0489-1
References & Citations
Ding W., et al. (2009) Hepatology. 49 (4) :1277-86. ; ; Tomasi ML., et al. (2009) Gastroenterology. 136 (3) :1025-36.;
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 1mM DTT, 0.1M NaCl, 10% glycerol
Scientific Category
Metabolism
NCBI Accession Number
NP_000420.1
Uniprot Accession Number
Q00266
Species
Human
AA Sequence
MNGPVDGLCD HSLSEGVFMF TSESVGEGHP DKICDQISDA VLDAHLKQDP NAKVACETVC KTGMVLLCGE ITSMAMVDYQ RVVRDTIKHI GYDDSAKGFD FKTCNVLVAL EQQSPDIAQC VHLDRNEEDV GAGDQGLMFG YATDETEECM PLTIILAHKL NARMADLRRS GLLPWLRPDS KTQVTVQYMQ DNGAVIPVRI HTIVISVQHN EDITLEEMRR ALKEQVIRAV VPAKYLDEDT VYHLQPSGRF VIGGPQGDAG VTGRKIIVDT YGGWGAHGGG AFSGKDYTKV DRSAAYAARW VAKSLVKAGL CRRVLVQVSY AIGVAEPLSI SIFTYGTSQK TERELLDVVH KNFDLRPGVI VRDLDLKKPI YQKTACYGHF GRSEFPWEVP RKLVF

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