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Recombinant human PTS protein

CAT: 0112-ATGP0452-500Size: 500 µgDry Ice: NoHazardous: No
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CAT#:0112-ATGP0452-500Size:500 µg
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Description
6-Pyruvoyltetrahydropterin synthase (PTS), also known as PTPS, belongs to the family of lyases, specifically those carbon-oxygen lyases acting on phosphates. The enzyme encoded by this gene catalyzes the elimination of inorganic triphosphate from dihydroneopterin triphosphate, which is the second and irreversible step in the biosynthesis of tetrahydrobiopterin from GTP. Tetrahydrobiopterin, also known as BH (4), is an essential cofactor and regulator of various enzyme activities, including enzymes involved in serotonin biosynthesis and NO synthase activity. Mutations in this gene result in hyperphenylalaninemia. Recombinant human PTS, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.
Product Name Alternative
6-pyruvoyltetrahydropterin synthase, PTPS, PTP synthase, 6-pyruvoyltetrahydropterin synthase 6 pyruvoyl tetrahydrobiopterin synthase, 6 pyruvoyl tetrahydropterin synthase, 6 pyruvoyltetrahydropterin synthase, EC 4.2.3.12, FLJ97081
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
1 mg/mL (determined by Bradford assay)
Purity
> 90% by SDS-PAGE
Molecular Weight
18.5 kDa (165aa) confirmed by MALDI-TOF
Additionnal Information
PTS, 6-pyruvoyltetrahydropterin synthase, PTPS, PTP synthase, 6-pyruvoyltetrahydropterin synthase 6 pyruvoyl tetrahydrobiopterin synthase, 6 pyruvoyl tetrahydropterin synthase, 6 pyruvoyltetrahydropterin synthase, EC 4.2.3.12, FLJ97081, ATGP0452-10 µg, ATGP0452-20 µg, ATGP0452-50 µg, ATGP0452-100 µg, ATGP0452-250 µg, ATGP0452-500 µg, ATGP0452-1 mg, ATGP0452-10, ATGP0452-20, ATGP0452-50, ATGP0452-100, ATGP0452-250, ATGP0452-500, ATGP0452-1
References & Citations
Thony B., et al. (1992) Biochem Biophys Res Commun. 189:1437-43. ; ; Milstien S., et al. (1989) J Biol Chem. 264 (14) :8066-73.;
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 1mM DTT, 20% glycerol
Scientific Category
Signal Transduction
NCBI Accession Number
NP_000308
Uniprot Accession Number
Q03393
Species
Human
AA Sequence
MSTEGGGRRC QAQVSRRISF SASHRLYSKF LSDEENLKLF GKCNNPNGHG HNYKVVVTVH GEIDPATGMV MNLADLKKYM EEAIMQPLDH KNLDMDVPYF ADVVSTTENV AVYIWDNLQK VLPVGVLYKV KVYETDNNIV VYKGE

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