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Recombinant human SAP18 protein

CAT: 0112-ATGP0340-020Size: 20 µgDry Ice: NoHazardous: No
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CAT#:0112-ATGP0340-020Size:20 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SAP18, also known as Sin3A-associated protein, is component of the histone deacetylase complex that plays an important role in the regulation of eukaryotic gene expression. This protein directly interacts with SIN3 and enhances SIN3-mediated transcriptional repression when tethered to the promoter. It also has been shown to play a key role in gene-specific recruitment of the HDAC complex by a number of transcription factors including Gli, GAGA, and Bicoid. Recombinant SAP18 protein was expressed in E. coli and purified by using conventional chromatography techniques.
Product Name Alternative
Sin3A-associated protein 18kDa, Sin3A-associated protein, 2HOR0202, SAP18P, SAP18, Sin3A-associated protein, 18kDa Histone deacetylase complex subunit SAP18, Sin3-associated polypeptide p18.
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
0.5 mg/mL (determined by Bradford assay)
Endotoxin
< 1 EU per 1ug of protein (determined by LAL method)
Purity
> 90% by SDS-PAGE
Molecular Weight
19.7 kDa (173aa) confirmed by MALDI-TOF
Additionnal Information
SAP18, Sin3A-associated protein 18kDa, Sin3A-associated protein, 2HOR0202, SAP18P, SAP18, Sin3A-associated protein, 18kDa Histone deacetylase complex subunit SAP18, Sin3-associated polypeptide p18., ATGP0340-10 µg, ATGP0340-20 µg, ATGP0340-50 µg, ATGP0340-100 µg, ATGP0340-250 µg, ATGP0340-500 µg, ATGP0340-1 mg, ATGP0340-10, ATGP0340-20, ATGP0340-50, ATGP0340-100, ATGP0340-250, ATGP0340-500, ATGP0340-1
References & Citations
Zhang Y., et al. (1997) Cell. 89 (3) :357-64. ; ; Matyash A, et al. (2009) J Biol Chem. 284 (5) :3012-20.;
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 0.1M NaCl, 30% glycerol, 1mM DTT
Scientific Category
Epigenomics (Transcription & Translation)
NCBI Accession Number
NP_005861.2
Uniprot Accession Number
O00422
Species
Human
AA Sequence
MAVESRVTQE EIKKEPEKPI DREKTCPLLL RVFTTNNGRH HRMDEFSRGN VPSSELQIYT WMDATLKELT SLVKEVYPEA RKKGTHFNFA IVFTDVKRPG YRVKEIGSTM SGRKGTDDSM TLQSQKFQIG DYLDIAITPP NRAPPPSGRM RPY

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