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Human DKK3 antibody

CAT: 0112-ATGA0476-100Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0112-ATGA0476-100Size:100 µL
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Description
Dickkopf-related protein 3, also known as DKK3, is a member of the DKK protein family including Dkk-1, 2, 3 and -4. It is a secreted protein with two cysteine rich regions and is involved in embryonic development through its inhibition of the WNT signaling pathway. DKK3 is a 350 amino acid secreted glycoprotein that is composed of an N-terminal signal peptide and two conserved cysteine-rich domains, which are separated by a 12 amino acid linker region. The expression of this gene is decreased in a variety of cancer cell lines and it may function as a tumor suppressor gene.
Product Name Alternative
Dickkopf WNT signaling pathway inhibitor 3, Dickkopf-related protein 3, Dickkopf-3, Dkk-3, REIC, RIG, CRRL
Host
Mouse
Antigen Species
Human
Reactivity
Human
Immunogen
Recombinant human DKK3 (22-350aa) purified from E. coli
Clonality
Monoclonal
Isotype
IgG1 κ
Clone
AT103B5
Conjugation
Unconjugated
Applications
ELISA, WB
Purification Method
By protein-A affinity chromatography
Concentration
1 mg/mL (determined by BCA assay)
Additionnal Information
Cardiomyocyte regeneration-related lncRNA, CRRL, Dickkopf, Dickkopf 3 homolog, Dickkopf WNT signaling pathway inhibitor 3, Dickkopf-3, Dickkopf-related protein 3, Dickkopf-related protein 3 precursor, DKK3, Dkk-3, Regulated in glioma, REIC, RIG, Xenopus laevis, Xenopus laevis homolog 3, ATGA0476-10 µg, ATGA0476-20 µg, ATGA0476-50 µg, ATGA0476-100 µg, ATGA0476-250 µg, ATGA0476-500 µg, ATGA0476-1 mg, ATGA0476-010, ATGA0476-020, ATGA0476-050, ATGA0476-100, ATGA0476-250, ATGA0476-500, ATGA0476-01M
References & Citations
Cadigan K M., et al. (1997) Genes Dev. 11: 3286-3305.; ; Gilnka A., et al. (1998) Nature. 391: 357-362.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. Phosphate-Buffered Saline (pH 7.4) with 0.02% Sodium Azide, 10% glycerol
Applications Notes
The antibody has been tested by ELISA and Western blot analysis to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results.
Scientific Category
Signal Transduction
NCBI Accession Number
NP_001018067
Uniprot Accession Number
Q9UBP4
WB Description
The cell and tissue lysates (40ug) were resolved by SDS-PAGE, transferred to PVDF membrane and probed with anti-human DKK3 antibody (1:1000) . Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system.; ; Lane 1.: 293T cell lysate; ; Lane 2.: HepG2 cell lysate; ; Lane 3.: MCF7 cell lysate; ; Lane 4.: A549 cell lysate; ; Lane 5.: Mouse brain tissue lysate; ; Lane 6.: Mouse kidney tissue lysate

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