Products for Research Use Only
RegisterLogin

Human IL-6 antibody

CAT: 0112-ATGA0313-100Size: 100 µLDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0112-ATGA0313-100Size:100 µL
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Interleukin-6, or IL-6, is a multifunctional protein, 212 amino acids in length that plays critical roles in host defense, immune response and hematopoiesis. interleukin-6 (IL-6) produced by T cells, macrophages, fibroblasts, endothelial and other cells. IL-6 induces proliferation or differentiation in many cell types including B cells, thymocytes and T cells. IL-6, in concert with TGF-Beta, is important for developing Th17 responses. The IL-6 receptor is a trimeric complex composed of an IL-6-specific a chain and a homodimer of the gp130 glycoprotein common to the IL-6, IL-11, CNTF, OSM and LIF receptors. Stimulation with IL-6 leads to gp130 homodimerization and the activation of associated kinases JAK1 and JAK2. Once activated, JAK1 and JAK2 phosphorylate Stat3, causing its nuclear translocation and transcription of Stat3-responsive genes. IL-6 has also been shown to activate the Ras/MAP kinase pathway, which regulates NFIL6 transcription.
Product Name Alternative
Interleukin-6, B-cell stimulatory factor 2, BSF-2, CTL differentiation factor, CDF, Hybridoma growth factor, Interferon beta-2, IFN-beta-2, IFNB2, HGF, HSF
Host
Mouse
Antigen Species
Human
Reactivity
Human
Immunogen
Recombinant human Interleukin 6 (30-212aa) purified from E. coli
Clonality
Monoclonal
Isotype
IgG1 κ
Clone
AT1F10
Conjugation
Unconjugated
Applications
ELISA, WB
Purification Method
By protein-A affinity chromatography
Concentration
1 mg/mL (determined by BCA assay)
Additionnal Information
VLAB, VLA-4 subunit bet, VLA4 subunit bet, VLA 4 subunit bet, MSK12, MSK 12, MDF2, Interleukin-6, Interleukin6, Interleukin 6, Interferon beta 2, Integrin beta1, Integrin beta 1, IL-6, IL6, IL 6, IFNB2, IFNB 2, IFN B2, IFN B 2, I L6, HSF, HGF, GPIIA, GP IIA, Glycoprotein Iia, FNRB, Fibronectin receptor subunit beta, CD29, BSF2, BSF 2, ATGA0313-10 µg, ATGA0313-20 µg, ATGA0313-50 µg, ATGA0313-100 µg, ATGA0313-250 µg, ATGA0313-500 µg, ATGA0313-1 mg, ATGA0313-010, ATGA0313-020, ATGA0313-050, ATGA0313-100, ATGA0313-250, ATGA0313-500, ATGA0313-01M
References & Citations
Heinrich P.C., et al. (1998) Biochem J 334: 297-314; ; Heinrich P.C., et al. (1998) Z Ernahrungswiss 37: 43-49; ; Jones S.A. (2005) J Immunol 175: 3463-3468
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. Phosphate-Buffered Saline (pH 7.4) with 0.02% Sodium Azide, 10% glycerol
Applications Notes
The antibody has been tested by ELISA, Western blot analysis to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results. Recommended starting dilution is 1:1000.
Scientific Category
Hormones & Cytokines
NCBI Accession Number
NP_000591
Uniprot Accession Number
P05231
WB Description
The Human IL6 recombinant protein (10ng) was resolved by SDS-PAGE, transferred to PVDF membrane and probed with anti-human Interleukin 6 antibody (1:1000) . Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system.

Related Products

CatalogName
ATGP0352-250Recombinant human IL-6 protein
ATGP0352-100Recombinant human IL-6 protein
ATGP3278-010Recombinant human IL-6 protein
ATGP3256-020Recombinant human IL-6 protein
ATGP0352-020Recombinant human IL-6 protein
ATGP3278-050Recombinant human IL-6 protein
ATGP3278-020Recombinant human IL-6 protein
ATGP3256-500Recombinant human IL-6 protein
ATGP3256-100Recombinant human IL-6 protein
ATGP3256-050Recombinant human IL-6 protein

Alternative Products

CatalogName
OASB01222-500UGHuman IL-6 Antibody
13122-05011Human Interleukin-6 (IL-6) Antibody
bsm-10807MHuman IL-6 Monoclonal Antibody
STJ15100093Anti-human IL-6 antibody
DA013Human IL-6 Antibody (19D6)
DA097Human IL-6 Antibody (15H5)
GTR18715969-01PE human IL-6 Antibody
HY-P86691Human IL-6 Antibody (YA6383)
OASB01223-500UGHuman IL-6 Antibody : Biotin
GTR18293883IL-6 Human Antibody (Capture)

Popular Products