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Human MFAP4 antibody

CAT: 0112-ATGA0268-100Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0112-ATGA0268-100Size:100 µL
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Description
Several microfibril associated proteins (MFAPs) have been cloned, including MFAP1, MFAP3 and MFAP4. The MFAP1 and MFAP3 genes are localized near the fibrillin genes FBN1 and FBN2, respectively. Mutations in FBN1 are linked to Marfan syndrome. Mutations in FBN2 have been linked to congenital contractural arachnodactyly. This suggests roles for MFAP1 and MFAP3 in heritable diseases affecting microfibrils. Deletion of MFAP4 was found in 30 of 31 patients with Smith-Magenis syndrome (SMS), a clinically recognizable multiple congenital anomaly/mental retardation syndrome. Also, MFAP4 play an important role in calcium-dependent cell adhesion or intercellular interactions. These structural features of MFAP4 suggest that it is an extracellular matrix protein involved in cell adhesion or intercellular interactions.
Product Name Alternative
Microfibrillar-associated protein 4, microfibrillar-associated protein 4, Microfibril associated glycoprotein 4, Microfibril-associated glycoprotein 4
Host
Mouse
Antigen Species
Human
Reactivity
Human
Immunogen
Recombinant human MFAP4 (22-255aa) purified from E. coli
Clonality
Monoclonal
Isotype
IgG1 κ
Clone
AT12D11
Conjugation
Unconjugated
Applications
ELISA, WB
Purification Method
By protein-A affinity chromatography
Concentration
1 mg/mL (determined by BCA assay)
Additionnal Information
MFAP4, ATGA0268-10 µg, ATGA0268-20 µg, ATGA0268-50 µg, ATGA0268-100 µg, ATGA0268-250 µg, ATGA0268-500 µg, ATGA0268-1 mg, ATGA0268-10, ATGA0268-20, ATGA0268-50, ATGA0268-100, ATGA0268-250, ATGA0268-500, ATGA0268-1
References & Citations
Zhao, Z., et al. (1995) Hum Mol Genet 4 (4) : 589-97.; ; Kasamatsu, S., et al. (2011) Sci Rep 1:164.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. Phosphate-Buffered Saline (pH 7.4) with 0.02% Sodium Azide, 10% glycerol
Applications Notes
The antibody has been tested by ELISA and Western blot analysis to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results.
Scientific Category
Signal Transduction
NCBI Accession Number
NP_002395
Uniprot Accession Number
P55083
WB Description
The tissue lysate of lung (30ug) was resolved by SDS-PAGE, transferred to PVDF membrane and probed with anti-human MFAP4 antibody (1:1000) . Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system.

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