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Human KLF7 antibody

CAT: 0112-ATGA0256-100Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0112-ATGA0256-100Size:100 µL
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Description
KLK7 is a member of the Kruppel-like transcriptional regulator family. Members in this family regulate cell proliferation, differentiation, survival and the development of nervous systems. and contain three C2H2 zinc fingers at the C-terminus that mediate binding to GC-rich sites. KLF7 is binds specifically to an Ikaros core binding element that is crucial for in vivo NTRK1/TrkA enhancer function. This protein may contribute to the progression of type 2 diabetes by inhibiting insulin expression and secretion in pancreatic beta-cells and by deregulating adipocytokine secretion in adipocytes. A pseudogene of this gene is located on the long arm of chromosome 3. Alternative splicing results in multiple transcript variants.
Product Name Alternative
Kruppel-like factor 7, uKLF
Host
Mouse
Antigen Species
Human
Reactivity
Human
Immunogen
Recombinant human KLF7 (1-302aa) purified from E. coli
Clonality
Monoclonal
Isotype
IgG1 κ
Clone
AT3G3
Conjugation
Unconjugated
Applications
ELISA, WB
Purification Method
By protein-A affinity chromatography
Concentration
1 mg/mL (determined by BCA assay)
Additionnal Information
KLF7, ATGA0256-10 µg, ATGA0256-20 µg, ATGA0256-50 µg, ATGA0256-100 µg, ATGA0256-250 µg, ATGA0256-500 µg, ATGA0256-1 mg, ATGA0256-10, ATGA0256-20, ATGA0256-50, ATGA0256-100, ATGA0256-250, ATGA0256-500, ATGA0256-1
References & Citations
Matsumoto, N., et al. (1998) J Biol Chem 273 (43) : 28229-37.; ; Kanazawa, A., et al. (2005) Diabetologia 48 (7) : 1315-22.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. Phosphate-Buffered Saline (pH 7.4) with 0.02% Sodium Azide, 10% glycerol
Applications Notes
The antibody has been tested by ELISA and Western blot analysis to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results.
Scientific Category
Epigenomics (Transcription & Translation)
NCBI Accession Number
NP_003700
Uniprot Accession Number
O75840
WB Description
The tissue lysate of mouse brain (40ug) was resolved by SDS-PAGE, transferred to PVDF membrane and probed with anti-human KLF7 antibody (1:1000) . Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system.

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