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Human LSM2 antibody

CAT: 0112-ATGA0226-100Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0112-ATGA0226-100Size:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
LSM2 is a member of the LSm family of RNA-binding proteins. Component of LSm protein complexes, which are involved in RNA processing and may function in a chaperone-like manner. Component of the cytoplasmic complex which is thought to be involved in mRNA degradation by activating the decapping step. Component of the nuclear LSM2 complex, which is involved in splicing of nuclear mRNAs. LSM2 associates with multiple snRNP complexes containing the U6 snRNA It binds directly to the U6 snRNA and plays a role in the biogenesis and stability of the U6 snRNP and U4/U6 snRNP complexes. It probably also is involved degradation of nuclear pre-mRNA by targeting them for decapping. LSM2 binds specifically to the 3'-terminal U-tract of U6 snRNA. LSM2-LSM8 probably is involved in processing of pre-tRNAs, pre-rRNAs and U3 snoRNA.
Product Name Alternative
U6 snRNA-associated Sm-like protein LSm2, Protein G7b, Small nuclear ribonuclear protein D homolog, snRNP core Sm-like protein Sm-x5, C6orf28, YBL026W
Host
Mouse
Antigen Species
Human
Reactivity
Human
Immunogen
Recombinant human LSm2 (1-95aa) purified from E. coli
Clonality
Monoclonal
Isotype
IgG2a κ
Clone
1G7
Conjugation
Unconjugated
Applications
ELISA, WB
Purification Method
By protein-G affinity chromatography
Concentration
1 mg/mL (determined by BCA assay)
Additionnal Information
C6orf28, G7b, LSm2, Protein G7b, Small nuclear ribonuclear protein D homolog, snRNP, snRNP core Sm-like protein Sm-x5, u6 snRNA-associated Sm-like protein LSm2, YBL026W, ATGA0226-10 µg, ATGA0226-20 µg, ATGA0226-50 µg, ATGA0226-100 µg, ATGA0226-250 µg, ATGA0226-500 µg, ATGA0226-1 mg, ATGA0226-010, ATGA0226-020, ATGA0226-050, ATGA0226-100, ATGA0226-250, ATGA0226-500, ATGA0226-01M
References & Citations
Luhtala N, Parker R.Nucleic Acids Res. 2009 Sep 37 (16) :5529-36.; ; Fernandez CF, Pannone BK, Chen X, Fuchs G, Wolin SL .Mol Biol Cell. 2004Jun 15 (6) :2842-52.; ; Achsel T., et al. (1999) EMBO J. 18:5789-5802.;
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. Phosphate-Buffered Saline (pH 7.4) with 0.02% Sodium Azide, 10% glycerol
Applications Notes
The antibody has been tested by ELISA and Western blot analysis to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results.
Scientific Category
Epigenomics (Transcription & Translation)
NCBI Accession Number
NP_067000
Uniprot Accession Number
Q9Y333
WB Description
The cell lysates (20 µg) were resolved by SDS-PAGE, transferred to PVDF membrane and probed with anti-human LSm2 antibody (1:1,000) . Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system.; ; Lane 1.: MCF7 cell lysate; ; Lane 2.: HeLa cell lysate; ; Lane 3.: 293T cell lysate;

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