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Human KCTD15 antibody

CAT: 0112-ATGA0121-100Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0112-ATGA0121-100Size:100 µL
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Description
KCTD15 (Potassium channel tetramerisation domain containing 15, also known as BTB/POZ domain-containing protein KCTD15) is protein that in humans is encoded by the KCTD15 gene. KCTD15 is expressed at high level in brain and hypothalamus. The potassium channel KCTD15 was identified as a genetic loci associated with higher than normal body mass index (BMI) in humans along with genes such as GNPDA2, MTCH2, FTO, and TMEM18. Single nucleotide polymorphisms (SNPs) in non-diabetic and diabetic patients showed that FTO was most strongly associated with obesity while MTCH2 and GNPDA2 were still significantly associated with higher than normal BMI levels.
Product Name Alternative
BTB/POZ domain-containing protein KCTD15, MGC25497, MGC2628
Host
Mouse
Antigen Species
Human
Reactivity
Human
Immunogen
Recombinant human KCTD15 (1-159aa) purified from E. coli
Clonality
Monoclonal
Isotype
IgG2b κ
Clone
AT2B11
Conjugation
Unconjugated
Applications
ELISA, WB, ICC/IF, FACS
Purification Method
By protein-G affinity chromatography
Concentration
1 mg/mL (determined by BCA assay)
Additionnal Information
KCTD15, ATGA0121-10 µg, ATGA0121-20 µg, ATGA0121-50 µg, ATGA0121-100 µg, ATGA0121-250 µg, ATGA0121-500 µg, ATGA0121-1 mg, ATGA0121-10, ATGA0121-20, ATGA0121-50, ATGA0121-100, ATGA0121-250, ATGA0121-500, ATGA0121-1
References & Citations
Elks CE, et al. (2010) PLoS Med. 7 (5) : e1000284.; ; Strausberg RL, et al. (2002) Proc. Natl. Acad. Sci. U.S.A, 99 (26) : 16899-903.; ; Willer CJ, et al. (2010) Nat. Genet, 41 (1) : 24-34.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. Phosphate-Buffered Saline (pH 7.4) with 0.02% Sodium Azide, 10% glycerol
Applications Notes
The antibody has been tested by ELISA, Western blot, ICC/IF and FACS analysis to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results.
Scientific Category
Neuroscience
NCBI Accession Number
NP_076981
Uniprot Accession Number
Q96SI1
WB Description
The cell lysates (40ug) were resolved by SDS-PAGE, transferred to PVDF membrane and probed with anti-human KCTD15 (1:1000) . Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system.; ; Lane 1 : HeLa cell lysate; ; Lane 2 : NIH/3T3 cell lysate; ; Lane 3 : K562 cell lysate
FACS Description
Flow cytometry analysis of KCTD15 in HeLa cells. The cell was stained with ATGA0121 at 2-5ug for 1x10^6cells (red) . A Goat anti mouse IgG (Alexa fluor 488) was used as the secondary antibody. Mouse monoclonal IgG was used as the isotype control (dark gray), cells without incubation with primary and secondary antibody was used as the negative control (light gray) .
IF Description
ICC/IF analysis of KCTD15 in HeLa cells. The cell was stained with ATGA0121 (1:100) . The secondary antibody (green) was used Alexa Fluor 488.

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